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Physical activity and breast cancer survival: an epigenetic link through reduced methylation of a tumor suppressor gene L3MBTL1

Overview of attention for article published in Breast Cancer Research and Treatment, August 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

news
1 news outlet
twitter
8 tweeters
facebook
4 Facebook pages
wikipedia
1 Wikipedia page

Citations

dimensions_citation
51 Dimensions

Readers on

mendeley
127 Mendeley
citeulike
1 CiteULike
Title
Physical activity and breast cancer survival: an epigenetic link through reduced methylation of a tumor suppressor gene L3MBTL1
Published in
Breast Cancer Research and Treatment, August 2011
DOI 10.1007/s10549-011-1716-7
Pubmed ID
Authors

Hongmei Zeng, Melinda L. Irwin, Lingeng Lu, Harvey Risch, Susan Mayne, Lina Mu, Qian Deng, Luca Scarampi, Marco Mitidieri, Dionyssios Katsaros, Herbert Yu

Abstract

The study was conducted to determine the effect of physical activity on DNA methylation and to predict the consequence of this effect concerning gene expression and breast cancer survival. Blood samples, collected from 12 breast cancer patients who participated in a randomized clinical trial of exercise, were examined for exercise-related changes in DNA methylation using a methylation microarray. Tumor samples of 348 breast cancer patients were analyzed with qRT-PCR and qMSP to determine gene expression and methylation identified in the microarray analysis. Cox regression models were developed to predict survival outcomes in association with gene expression and methylation. After 6 months of moderate-intensity aerobic exercise, changes in DNA methylation (P < 5 × 10(-5)) in peripheral blood leukocytes were detected in 43 genes from a panel of 14 495. Based on the list, we analyzed gene expression in association with overall survival in breast tumors and found three genes whose methylation was reduced after exercise were favorably in association with overall survival, i.e., higher expression associated with better survival. Of the three genes, L3MBTL1 was a putative tumor suppressor gene with known function to repress chromatin for transcription, which is activated mainly in germline stem cells. Further analyses of tumor features among patients indicated that high expression of L3MBTL1 was associated with low grade and hormone receptor-positive tumors, as well as low risk of disease recurrence and breast cancer death. In conclusion, the study suggests that increasing physical activity after a breast cancer diagnosis may affect epigenetic regulation of tumor suppressor genes, which have favorable impacts on survival outcomes of breast cancer patients.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 2 2%
Portugal 2 2%
United States 2 2%
Uruguay 2 2%
Switzerland 1 <1%
Unknown 118 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 30 24%
Researcher 28 22%
Student > Master 19 15%
Student > Bachelor 13 10%
Professor > Associate Professor 11 9%
Other 26 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 42 33%
Medicine and Dentistry 31 24%
Biochemistry, Genetics and Molecular Biology 21 17%
Unspecified 8 6%
Sports and Recreations 5 4%
Other 20 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 July 2018.
All research outputs
#691,975
of 12,422,413 outputs
Outputs from Breast Cancer Research and Treatment
#112
of 3,126 outputs
Outputs of similar age
#4,900
of 85,963 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#4
of 55 outputs
Altmetric has tracked 12,422,413 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,126 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 85,963 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.