Title |
Nanomaterials for the Capture and Therapeutic Targeting of Circulating Tumor Cells
|
---|---|
Published in |
Cellular and Molecular Bioengineering, July 2017
|
DOI | 10.1007/s12195-017-0497-4 |
Pubmed ID | |
Authors |
Zhenjiang Zhang, Michael R. King |
Abstract |
Circulating tumor cells are a hallmark of cancer metastasis which accounts for approximately 90% of all cancer-related deaths. Their detection and characterization have significant implications in cancer biology and clinical practice. However, CTCs are rare cells and consist of heterogeneous subpopulations, requiring highly sensitive and specific techniques to identify and isolate them with high efficiency. Nanomaterials, with unique structural and functional properties, have shown strong promise to meet the challenging demands. In this review, we discuss CTC capture and therapeutic targeting, emphasizing the significance of the nanomaterials being used for this purpose. The next generation of therapy for metastatic cancer may well involve capturing and even directly neutralizing CTCs using nanomaterials. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 33% |
Ireland | 1 | 7% |
Saudi Arabia | 1 | 7% |
Germany | 1 | 7% |
Kuwait | 1 | 7% |
Unknown | 6 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 9 | 60% |
Scientists | 3 | 20% |
Science communicators (journalists, bloggers, editors) | 2 | 13% |
Practitioners (doctors, other healthcare professionals) | 1 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 46 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 15% |
Student > Master | 6 | 13% |
Student > Bachelor | 6 | 13% |
Student > Doctoral Student | 4 | 9% |
Researcher | 3 | 7% |
Other | 2 | 4% |
Unknown | 18 | 39% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 7 | 15% |
Biochemistry, Genetics and Molecular Biology | 6 | 13% |
Engineering | 4 | 9% |
Chemistry | 3 | 7% |
Medicine and Dentistry | 2 | 4% |
Other | 5 | 11% |
Unknown | 19 | 41% |