↓ Skip to main content

Structural and activity variability of fractions with different charge density and chain length from pharmaceutical heparins

Overview of attention for article published in Glycoconjugate Journal, May 2017
Altmetric Badge

Mentioned by

facebook
1 Facebook page

Readers on

mendeley
7 Mendeley
Title
Structural and activity variability of fractions with different charge density and chain length from pharmaceutical heparins
Published in
Glycoconjugate Journal, May 2017
DOI 10.1007/s10719-017-9774-7
Pubmed ID
Authors

Yanlei Yu, Makoto Hirakane, Daisuke Mori, Lei Lin, Fuming Zhang, Hong Zhang, Robert J. Linhardt

Abstract

Heparin is a structurally complex polysaccharide used as a clinical anticoagulant. It is comprised of a heterogeneous mixture of polysaccharide chains having a variety of sequences and lengths. The production methods and regulatory controls of pharmaceutical heparins have changed over the years. This study assesses the structural and activity uniformity of the polysaccharide chains comprising two contemporary heparin products. The heparin fractions with different sizes and charges were separated with size exclusion and ion exchange chromatography. The fractions were analyzed for their molecular weight properties, di- and tetrasaccharide compositions, and anti-factor IIa and anti-factor-Xa activities. The distribution of these properties through chains of different lengths and ones with different charge density were compared. The results demonstrate that with the increase in heparin purity, activity and molecular weight required by the current pharmacopeia, the uniformity of pharmaceutical heparin products have increased.

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 43%
Other 2 29%
Student > Doctoral Student 1 14%
Student > Ph. D. Student 1 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 43%
Agricultural and Biological Sciences 2 29%
Medicine and Dentistry 1 14%
Engineering 1 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2017.
All research outputs
#10,189,681
of 11,483,620 outputs
Outputs from Glycoconjugate Journal
#492
of 559 outputs
Outputs of similar age
#220,384
of 261,548 outputs
Outputs of similar age from Glycoconjugate Journal
#9
of 12 outputs
Altmetric has tracked 11,483,620 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 559 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 261,548 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.