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Probiotics, prebiotics and the gastrointestinal tract in health and disease

Overview of attention for article published in Inflammopharmacology, March 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#21 of 269)
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

blogs
1 blog
twitter
10 tweeters
facebook
2 Facebook pages

Citations

dimensions_citation
28 Dimensions

Readers on

mendeley
121 Mendeley
Title
Probiotics, prebiotics and the gastrointestinal tract in health and disease
Published in
Inflammopharmacology, March 2014
DOI 10.1007/s10787-014-0201-4
Pubmed ID
Authors

Luis Vitetta, David Briskey, Hollie Alford, Sean Hall, Samantha Coulson

Abstract

The microbiome located in the human gastrointestinal tract (GIT) comprises the largest community (diverse and dense) of bacteria, and in conjunction with a conducive internal milieu, promotes the development of regulated pro- and anti-inflammatory signals within the GIT that promotes immunological and metabolic tolerance. In addition, host-microbial interactions govern GIT inflammation and provide cues for upholding metabolic regulation in both the host and microbes. Failure to regulate inflammatory responses can increase the risk of developing inflammatory conditions in the GIT. Here, we review clinical studies regarding the efficacy of probiotics/prebiotics and the role they may have in restoring host metabolic homeostasis by rescuing the inflammatory response. The clinical studies reviewed included functional constipation, antibiotic-associated diarrhoea, Clostridium difficile diarrhoea, infectious diarrhoea/gastroenteritis, irritable bowel syndrome, inflammatory bowel diseases and necrotizing enterocolitis. We have demonstrated that there was an overall reduction in risk when probiotics were administered over placebo in the majority of GIT inflammatory conditions. The effect size of a cumulative reduction in relative risk for the GIT conditions/diseases investigated was 0.65 (0.61-0.70) (z = 13.3); p < 0.0001 that is an average reduction in risk of 35 % in favour of probiotics. We also progress a hypothesis that the GIT comprises numerous micro-axes (e.g. mucus secretion, Th1/Th2 balance) that are in operational homeostasis; hence probiotics and prebiotics may have a significant pharmacobiotic regulatory role in maintaining host GIT homeostasis in disease states partially through reactive oxygen species signalling.

Twitter Demographics

The data shown below were collected from the profiles of 10 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 120 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 28 23%
Student > Bachelor 25 21%
Student > Master 20 17%
Unspecified 13 11%
Student > Ph. D. Student 11 9%
Other 24 20%
Readers by discipline Count As %
Medicine and Dentistry 35 29%
Agricultural and Biological Sciences 27 22%
Unspecified 13 11%
Nursing and Health Professions 11 9%
Biochemistry, Genetics and Molecular Biology 9 7%
Other 26 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 September 2016.
All research outputs
#834,155
of 13,020,606 outputs
Outputs from Inflammopharmacology
#21
of 269 outputs
Outputs of similar age
#14,824
of 189,821 outputs
Outputs of similar age from Inflammopharmacology
#1
of 5 outputs
Altmetric has tracked 13,020,606 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 269 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 189,821 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them