Title |
Synthesis, antioxidant and antimicrobial activities of novel thiopyrano[2,3-d]thiazoles based on aroylacrylic acids
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Published in |
Molecular Diversity, April 2017
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DOI | 10.1007/s11030-017-9737-8 |
Pubmed ID | |
Authors |
Andrii Lozynskyi, Viktoria Zasidko, Dmytro Atamanyuk, Danylo Kaminskyy, Halyna Derkach, Olexandr Karpenko, Volodymyr Ogurtsov, Roman Kutsyk, Roman Lesyk |
Abstract |
Here it is described the synthesis, antioxidant and antimicrobial activity determination of novel rel-([Formula: see text])-6-benzoyl-7-phenyl-2-oxo-3,5,6,7-tetrahydro-2H-thiopyrano[2,3-d]thiazole-5-carboxylic acids. The target compounds were obtained in good yields from 5-arylidene-4-thioxo-2-thiazolidinones and [Formula: see text]-aroylacrylic acids via regio- and diastereoselective hetero-Diels-Alder reaction. The stereochemistry of the cycloaddition was confirmed by NMR spectra. The antioxidant and antimicrobial activity screening identified 7 compounds (3c, 3e, 3f, 3g, 3k, 3l, 3p) with a high level of free radical scavenging (43-77% DPPH assay), and compounds with significant influence on Staphylococcus aureus, Bacillus subtilis and Candida albicans (MIC 3.13-6.25 [Formula: see text]), but slight effect on Escherichia coli. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 3 | 16% |
Researcher | 2 | 11% |
Professor > Associate Professor | 2 | 11% |
Student > Bachelor | 1 | 5% |
Professor | 1 | 5% |
Other | 4 | 21% |
Unknown | 6 | 32% |
Readers by discipline | Count | As % |
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Chemistry | 5 | 26% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 16% |
Biochemistry, Genetics and Molecular Biology | 2 | 11% |
Immunology and Microbiology | 1 | 5% |
Unspecified | 1 | 5% |
Other | 0 | 0% |
Unknown | 7 | 37% |