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Improvements in brain and behavior following eradication of hepatitis C

Overview of attention for article published in Journal of NeuroVirology, May 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

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3 tweeters

Citations

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9 Dimensions

Readers on

mendeley
18 Mendeley
Title
Improvements in brain and behavior following eradication of hepatitis C
Published in
Journal of NeuroVirology, May 2017
DOI 10.1007/s13365-017-0533-0
Pubmed ID
Authors

Taylor Kuhn, Philip Sayegh, Jacob D. Jones, Jason Smith, Manoj K. Sarma, A. Ragin, Elyse J. Singer, M. Albert Thomas, April D. Thames, Steven A. Castellon, Charles H. Hinkin

Abstract

Despite recent advances in treatment, hepatitis C remains a significant public health problem. The hepatitis C virus (HCV) is known to infiltrate the brain, yet findings from studies on associated neurocognitive and neuropathological changes are mixed. Furthermore, it remains unclear if HCV eradication improves HCV-associated neurological compromise. This study examined the longitudinal relationship between neurocognitive and neurophysiologic markers among healthy HCV- controls and HCV+ adults following successful HCV eradication. We hypothesized that neurocognitive outcomes following treatment would be related to both improved cognition and white matter integrity. Participants included 57 HCV+ participants who successfully cleared the virus at the end of treatment (sustained virologic responders [SVRs]) and 22 HCV- controls. Participants underwent neuropsychological testing and, for a nested subset of participants, neuroimaging (diffusion tensor imaging) at baseline and 12 weeks following completion of HCV therapy. Contrary to expectation, group-level longitudinal analyses did not reveal significant improvement in neurocognitive performance in the SVRs compared to the control group. However, a subgroup of SVRs demonstrated a significant improvement in cognition relative to controls, which was related to improved white matter integrity. Indeed, neuroimaging data revealed beneficial effects associated with clearing the virus, particularly in the posterior corona radiata and the superior longitudinal fasciculus. Findings suggest that a subgroup of HCV+ patients experienced improvements in cognitive functioning following eradication of HCV, which appears related to positive changes in white matter integrity. Future research should examine whether any additional improvements in neurocognition and white matter integrity among SVRs occur with longer follow-up periods.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 6%
Unknown 17 94%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 22%
Unspecified 4 22%
Student > Ph. D. Student 3 17%
Researcher 3 17%
Student > Doctoral Student 3 17%
Other 1 6%
Readers by discipline Count As %
Unspecified 4 22%
Neuroscience 4 22%
Psychology 4 22%
Medicine and Dentistry 3 17%
Biochemistry, Genetics and Molecular Biology 1 6%
Other 2 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 January 2018.
All research outputs
#6,992,919
of 12,390,159 outputs
Outputs from Journal of NeuroVirology
#281
of 614 outputs
Outputs of similar age
#123,496
of 269,224 outputs
Outputs of similar age from Journal of NeuroVirology
#1
of 10 outputs
Altmetric has tracked 12,390,159 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 614 research outputs from this source. They receive a mean Attention Score of 2.9. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,224 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them