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The role of intratumoral and systemic IL-6 in breast cancer

Overview of attention for article published in Breast Cancer Research and Treatment, March 2013
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (62nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

Mentioned by

twitter
2 tweeters

Citations

dimensions_citation
153 Dimensions

Readers on

mendeley
145 Mendeley
Title
The role of intratumoral and systemic IL-6 in breast cancer
Published in
Breast Cancer Research and Treatment, March 2013
DOI 10.1007/s10549-013-2488-z
Pubmed ID
Authors

Christine Dethlefsen, Grith Højfeldt, Pernille Hojman

Abstract

Chronic low-grade inflammation plays an important role in the pathogenesis of several cancer forms including breast cancer. The pleiotropic cytokine IL-6 is a key player in systemic inflammation, regulating both the inflammatory response and tissue metabolism during acute stimulations. Here, we review the associations between IL-6 and breast cancer ranging from in vitro cell culture studies to clinical studies, covering the role of IL-6 in controlling breast cancer cell growth, regulation of cancer stem cell renewal, as well as breast cancer cell migration. Moreover, associations between circulating IL-6 and risk of breast cancer, prognosis for patients with prevalent disease, adverse effects and interventions to control systemic IL-6 levels in patients are discussed. In summary, direct application of IL-6 on breast cancer cells inhibits proliferation in estrogen receptor positive cells, while high circulating IL-6 levels are correlated with a poor prognosis in breast cancer patients. This discrepancy reflects distinct roles of IL-6, with elevated systemic levels being a biomarker for tumor burden, physical inactivity, and impaired metabolism, while local intratumoral IL-6 signaling is important for controlling breast cancer cell growth, metastasis, and self renewal of cancer stem cells.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 145 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
Germany 1 <1%
Italy 1 <1%
Canada 1 <1%
Unknown 141 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 30 21%
Student > Bachelor 29 20%
Student > Master 26 18%
Researcher 19 13%
Unspecified 15 10%
Other 26 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 42 29%
Biochemistry, Genetics and Molecular Biology 28 19%
Medicine and Dentistry 24 17%
Unspecified 21 14%
Immunology and Microbiology 7 5%
Other 23 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2014.
All research outputs
#1,869,733
of 4,507,509 outputs
Outputs from Breast Cancer Research and Treatment
#433
of 1,163 outputs
Outputs of similar age
#43,944
of 122,227 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#14
of 36 outputs
Altmetric has tracked 4,507,509 research outputs across all sources so far. This one has received more attention than most of these and is in the 57th percentile.
So far Altmetric has tracked 1,163 research outputs from this source. They receive a mean Attention Score of 3.9. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 122,227 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.