Title |
Viruses and Multiple Sclerosis: From Mechanisms and Pathways to Translational Research Opportunities
|
---|---|
Published in |
Molecular Neurobiology, April 2017
|
DOI | 10.1007/s12035-017-0530-6 |
Pubmed ID | |
Authors |
Alexios-Fotios A. Mentis, Efthimios Dardiotis, Nikolaos Grigoriadis, Efthimia Petinaki, Georgios M. Hadjigeorgiou |
Abstract |
Viruses are directly or indirectly implicated in multiple sclerosis (MS). Here, we review the evidence on the virus-related pathophysiology of MS, introduce common experimental models, and explore the ways in which viruses cause demyelination. By emphasizing knowledge gaps, we highlight future research directions for effective MS diagnostics and therapies: (i) identifying biomarkers for at-risk individuals, (ii) searching for direct evidence of specific causative viruses, (iii) establishing the contribution of host genetic factors and viruses, and (iv) investigating the contribution of immune regulation at extra-CNS sites. Research in these areas is likely to be facilitated by the application of high-throughput technologies, the development of systems-based bioinformatic approaches, careful selection of experimental models, and the acquisition of high-quality clinical material for tissue-based research. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Unknown | 66 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 15% |
Researcher | 10 | 15% |
Student > Master | 7 | 10% |
Student > Bachelor | 7 | 10% |
Student > Doctoral Student | 6 | 9% |
Other | 10 | 15% |
Unknown | 17 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 13% |
Neuroscience | 8 | 12% |
Immunology and Microbiology | 7 | 10% |
Biochemistry, Genetics and Molecular Biology | 6 | 9% |
Agricultural and Biological Sciences | 6 | 9% |
Other | 9 | 13% |
Unknown | 22 | 33% |