Title |
Brain changes in overweight/obese and normal-weight adults with type 2 diabetes mellitus
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Published in |
Diabetologia, April 2017
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DOI | 10.1007/s00125-017-4266-7 |
Pubmed ID | |
Authors |
Sujung Yoon, Hanbyul Cho, Jungyoon Kim, Do-Wan Lee, Geon Ha Kim, Young Sun Hong, Sohyeon Moon, Shinwon Park, Sunho Lee, Suji Lee, Sujin Bae, Donald C. Simonson, In Kyoon Lyoo |
Abstract |
Overweight and obesity may significantly worsen glycaemic and metabolic control in type 2 diabetes. However, little is known about the effects of overweight and obesity on the brains of people with type 2 diabetes. Here, we investigate whether the presence of overweight or obesity influences the brain and cognitive functions during early stage type 2 diabetes. This study attempted to uncouple the effects of overweight/obesity from those of type 2 diabetes on brain structures and cognition. Overweight/obese participants with type 2 diabetes had more severe and progressive abnormalities in their brain structures and cognition during early stage type 2 diabetes compared with participants with normal weight. Relationships between each of these measures and disease duration were also examined. Global mean cortical thickness was lower in the overweight/obese type 2 diabetes group than in the normal-weight type 2 diabetes group (z = -2.96, p for group effect = 0.003). A negative correlation was observed between disease duration and global mean white matter integrity (z = 2.42, p for interaction = 0.02) in the overweight/obese type 2 diabetes group, but not in the normal-weight type 2 diabetes group. Overweight/obese individuals with type 2 diabetes showed a decrease in psychomotor speed performance related to disease duration (z = -2.12, p for interaction = 0.03), while normal-weight participants did not. The current study attempted to uncouple the effects of overweight/obesity from those of type 2 diabetes on brain structures and cognition. Overweight/obese participants with type 2 diabetes had more severe and progressive abnormalities in brain structures and cognition during early stage type 2 diabetes compared with normal-weight participants. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 29 | 19% |
Canada | 14 | 9% |
United Kingdom | 12 | 8% |
France | 5 | 3% |
Spain | 4 | 3% |
India | 4 | 3% |
Brazil | 4 | 3% |
South Africa | 3 | 2% |
Netherlands | 3 | 2% |
Other | 19 | 13% |
Unknown | 52 | 35% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 101 | 68% |
Practitioners (doctors, other healthcare professionals) | 27 | 18% |
Scientists | 19 | 13% |
Science communicators (journalists, bloggers, editors) | 2 | 1% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Unknown | 80 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 19 | 23% |
Researcher | 10 | 12% |
Student > Master | 9 | 11% |
Student > Bachelor | 7 | 9% |
Student > Doctoral Student | 4 | 5% |
Other | 8 | 10% |
Unknown | 24 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 19% |
Neuroscience | 9 | 11% |
Nursing and Health Professions | 6 | 7% |
Biochemistry, Genetics and Molecular Biology | 5 | 6% |
Psychology | 5 | 6% |
Other | 14 | 17% |
Unknown | 27 | 33% |