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Inhibition of monoamine oxidase-B by the polyphenolic compound, curcumin and its metabolite tetrahydrocurcumin, in a model of Parkinson’s disease induced by MPTP neurodegeneration in mice

Overview of attention for article published in Inflammopharmacology, April 2008
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#37 of 234)
  • High Attention Score compared to outputs of the same age (87th percentile)

Mentioned by

blogs
1 blog
patent
3 patents
reddit
1 Redditor

Citations

dimensions_citation
95 Dimensions

Readers on

mendeley
57 Mendeley
Title
Inhibition of monoamine oxidase-B by the polyphenolic compound, curcumin and its metabolite tetrahydrocurcumin, in a model of Parkinson’s disease induced by MPTP neurodegeneration in mice
Published in
Inflammopharmacology, April 2008
DOI 10.1007/s10787-007-1614-0
Pubmed ID
Authors

A. Rajeswari, M. Sabesan

Abstract

We investigated the effects of the polyphenolic compound curcumin and its metabolite tetrahydrocurcumin (ThC), in the model of Parkinson's disease induced in mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In this model depletion of dopamine(DA) and DOPAC (3,4-dihydroxy phenyl acetic acid)) occurs with increased monoamine oxidase (MAO-B) activity. We used HPLC with electrochemical detection to measure DA and DOPAC respectively while MAO-B was assayed by spectroflourimetry using the conversion of the fluorogenic substrate, kyuramine. Systemic administration of curcumin (80 mg/kg i. p.) and tetrahydrocurcumin (60 mg/kg i. p.) significantly reversed the MPTP-induced depletion of DA and DOPAC. The MAO-B activity was also significantly inhibited by these compounds. The results showed that curcumin and tetrahydrocurcumin reversed the MPTP induced depletion of DA and DOPAC which may in part be due to inhibition of MAO-B activity. In conclusion, both curcumin and its metabolite ThC exert neuroprotection against MPTP induced neurotoxicity.

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 2%
Unknown 56 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 32%
Student > Master 9 16%
Student > Doctoral Student 8 14%
Researcher 6 11%
Student > Bachelor 5 9%
Other 8 14%
Unknown 3 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 32%
Medicine and Dentistry 8 14%
Neuroscience 7 12%
Biochemistry, Genetics and Molecular Biology 6 11%
Pharmacology, Toxicology and Pharmaceutical Science 4 7%
Other 6 11%
Unknown 8 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2017.
All research outputs
#1,458,860
of 11,383,805 outputs
Outputs from Inflammopharmacology
#37
of 234 outputs
Outputs of similar age
#23,158
of 183,284 outputs
Outputs of similar age from Inflammopharmacology
#1
of 3 outputs
Altmetric has tracked 11,383,805 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 234 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 183,284 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them