| Title |
Ultra-low-dose sequential computed tomography for quantitative lung aeration assessment—a translational study
|
|---|---|
| Published in |
Intensive Care Medicine Experimental, April 2017
|
| DOI | 10.1186/s40635-017-0133-6 |
| Pubmed ID | |
| Authors |
Lorenzo Ball, Anja Braune, Francesco Corradi, Claudia Brusasco, Alessandro Garlaschi, Thomas Kiss, Thomas Bluth, Francesca Simonassi, Alice Bergamaschi, Jörg Kotzerke, Marcus J. Schultz, Marcelo Gama de Abreu, Paolo Pelosi |
| Abstract |
Quantitative lung computed tomography (CT) provides fundamental information about lung aeration in critically ill patients. We tested a scanning protocol combining reduced number of CT slices and tube current, comparing quantitative analysis and radiation exposure to conventional CT. In pigs, CT scans were performed during breath hold in a model of lung injury with three different protocols: standard spiral with 180 mAs tube current-time product (Spiral180), sequential with 20-mm distance between slices and either 180 mAs (Sequential180) or 50 mAs (Sequential50). Spiral scans of critically ill patients were collected retrospectively, and subsets of equally spaced slices were extracted. The agreement between CT protocols was assessed with Bland-Altman analysis. In 12 pigs, there was good concordance between the sequential protocols and the spiral scan (all biases ≤1.9%, agreements ≤±6.5%). In Spiral180, Sequential180 and Sequential50, estimated dose exposure was 2.3 (2.1-2.8), 0.21 (0.19-0.26), and 0.09 (0.07-0.10) mSv, respectively (p < 0.001 compared to Spiral180); number of acquired slices was 244 (227-252), 12 (11-13) and 12 (11-13); acquisition time was 7 (6-7), 23 (21-25) and 24 (22-26) s. In 32 critically ill patients, quantitative analysis extrapolated from 1-mm slices interleaved by 20 mm had a good concordance with the analysis performed on the entire spiral scan (all biases <1%, agreements ≤2.2%). In animal CT data, combining sequential scan and low tube current did not affect significantly the quantitative analysis, with a radiation exposure reduction of 97%, reaching a dose comparable to chest X-ray, but with longer acquisition time. In human CT data, lung aeration analysis could be extrapolated from a subset of thin equally spaced slices. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 2 | 25% |
| Student > Ph. D. Student | 2 | 25% |
| Student > Bachelor | 1 | 13% |
| Other | 1 | 13% |
| Professor | 1 | 13% |
| Other | 1 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 75% |
| Nursing and Health Professions | 1 | 13% |
| Environmental Science | 1 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 April 2017.
All research outputs
#15,452,475
of 22,962,258 outputs
Outputs from Intensive Care Medicine Experimental
#266
of 449 outputs
Outputs of similar age
#193,982
of 308,981 outputs
Outputs of similar age from Intensive Care Medicine Experimental
#6
of 8 outputs
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