But the study is a bit outdated and in dogs? Can we really assign a specific number to each individual?
RT @robertlufkinmd: When does aging begin? Aging reduces heart function which is required to run a marathon. World record times are the b…
RT @robertlufkinmd: When does aging begin? Aging reduces heart function which is required to run a marathon. World record times are the b…
When does aging begin? Aging reduces heart function which is required to run a marathon. World record times are the best for ~ 25 year olds and then decline after that age. Plot of record times vs age https://t.co/91fHyDmCGe https://t.co/GSFtT81BPc
I’ve spent years quantifying ageing. Different organs age differently. Skin peaks in early 20s. Bones peak at the age 30. Some brain faculties peak at around 50 years. Reg. running age-records, longer races have relatively older winners, more to do with
... and extended, with functional markers: Starting with: https://t.co/aU2njaZthC
@CSaid you might want to read about a study using Rapamycin for dog aging @ https://t.co/3OiGhiOlrN
Downhill after age 25...
RT @agingdoc1: @gshotwell @DogAgingProject A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middl…
@gshotwell @DogAgingProject A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs (2017) https://t.co/A7odfaksdX @GeroScienceAGE
When does aging begin? Aging reduces heart function which is required to run a marathon. World record times are the best for ~ 25 year olds and then decline after that age. Plot of record times vs age https://t.co/91fHyDmCGe https://t.co/t4uCLJ6TQI
So I should be able to do a 4hr marathon. Right? Right?!
When does aging begin? Age related cardiomyopathy reduces heart function. The marathon is a good test. The world record times are the shortest for 25 year olds and then degrade after that age. Plot of fastest race times vs age https://t.co/91fHyDmCG
Age-related cardiomyopathy is seen in animals from flies to humans. World Record Marathon times peak at ~25 yo. Rapamycin can partially reverse age-related heart dysfunction in mice and dogs. https://t.co/91fHyDmCGe https://t.co/CJlucZkhjL https://t.c
RT @robertlufkinmd: Age-related cardiomyopathy is seen in animals from flies to humans. World Record Marathon times peak at ~25 yo. Rapa…
RT @robertlufkinmd: Age-related cardiomyopathy is seen in animals from flies to humans. World Record Marathon times peak at ~25 yo. Rapa…
Some observations on your 'interpretation' on the 'dog-study' you cited.
RT @robertlufkinmd: Age-related cardiomyopathy is seen in animals from flies to humans. World Record Marathon times peak at ~25 yo. Rapa…
RT @robertlufkinmd: Age-related cardiomyopathy is seen in animals from flies to humans. World Record Marathon times peak at ~25 yo. Rapa…
Age-related cardiomyopathy is seen in animals from flies to humans. World Record Marathon times peak at ~25 yo. Rapamycin can partially reverse age-related heart dysfunction in mice and dogs. https://t.co/91fHyDmCGe https://t.co/CJlucZkhjL https://t.c
@CarDen1974 @robinyoungfun Looks like they used .1mg/kg in this study for the high dose group https://t.co/EYAqURvQzN
@dennishegstad @Molson_Hart Prob the right age to look into starting them on Rapamycin although you'll probably need to get it imported. https://t.co/F4HtsSmiIW
RT @ClarkSims12: 3) @mkaeberlein wrote this paper on using rapamycin in dogs. I think it is a land mark paper, because it shows rapamycin e…
3) @mkaeberlein wrote this paper on using rapamycin in dogs. I think it is a land mark paper, because it shows rapamycin extends life in larger mammals and treats caradiomyopathy in dogs. https://t.co/6H8d3sHPl6
@Maratosflier @LammingLab @RapaNews @BrienzaMark @CharlesMBrenner @davidasinclair We won't know for LS pending quality RCTs, but the evidence for healthspan (besides for ca) in model mammals is overwhelming. Start here: 1) https://t.co/5QMkdDX86k 2) http
@mike_lustgarten The paper concluding hypothesis that mTORC2 suppression & metabolic abnormalities can be avoided by intermittent dosing led to Lamming’s milestone: https://t.co/X8y4PyK7iy ➡️ dogs (3x/wk, Kaeberlein) https://t.co/A7odfaksdX ➡️perso
@mkaeberlein @MuscleScience At least the @DogAgingProject will combine exercise and rapamycin 😃 (https://t.co/xO1T2ckF9L for those who aren't already aware)
I'd emphasize even if reproduced this work pertains to a particular pathologic model hence does not undermine a multitude of pubs across labs & animal models, such as @mkaeberlein's work suggesting +🔼in E/A ratio, fractional shortening & ejection f
@drdewy @Blagosklonny @Punkmando1 These were N1’s obs only & was open label (no placebo) but if it’s real, you may find interesting @mkaeberlein’s https://t.co/A7odfaksdX & from his references in mice (Dai, 2014), (Flynn 2013) etc That’s why we ne
@th_stath @mkaeberlein My proposal of a minimum Cmax target ~25-75 ng/dL range is hypothesis: This speculation is based on LE in healthy genetically heterogeneous mice (which by contrast, are dosed *daily*) Will vary w/ condition & target tissue: htt
RT @StevePhillipsMD: Even short term rapamcyin treatment improved age-related heart dysfunction in dogs. https://t.co/8qu0fhog9t
Even short term rapamcyin treatment improved age-related heart dysfunction in dogs. https://t.co/8qu0fhog9t
RT @SilvanUrfer: New @DogAgingProject paper: 10 weeks of #rapamycin in dogs didn't cause side effects and improved heart function. https://…
RT @SilvanUrfer: New @DogAgingProject paper: 10 weeks of #rapamycin in dogs didn't cause side effects and improved heart function. https://…
Very nice summary of anti-aging studies. My favorite was the 3-year study of 218 humans, which found: "Calorie restriction caused a persistent and significant reduction from baseline to 2 years of all measured conventional cardiometabolic risk factors"
Serious fun: The Dog Aging Project and TOR/rapamycin: https://t.co/5RJKvFHWnZ https://t.co/Q4tJkrKC3O #LifeStagesGerosci
RT @sgkmacleod: reversing aging in dogs and mice evidence https://t.co/Ebqc7ietK4 - https://t.co/loNUGSuFJF - https://t.co/LBpU42Hy3H - htt…
RT @sgkmacleod: reversing aging in dogs and mice evidence https://t.co/Ebqc7ietK4 - https://t.co/loNUGSuFJF - https://t.co/LBpU42Hy3H - htt…
RT @HarbinBook: reversing aging in dogs and mice evidence https://t.co/pD9RyqWIFn - https://t.co/6gqnTc2kJ7 - https://t.co/vHUJK9fsgU - htt…
RT @scottmacleod: reversing aging in dogs and mice evidence https://t.co/pFXuAsFaoF - https://t.co/btJQZxLAKk - https://t.co/ixucHv8WTA - h…
RT @scottmacleod: reversing aging in dogs and mice evidence https://t.co/pFXuAsFaoF - https://t.co/btJQZxLAKk - https://t.co/ixucHv8WTA - h…
RT @sgkmacleod: reversing aging in dogs and mice evidence https://t.co/Ebqc7ietK4 - https://t.co/loNUGSuFJF - https://t.co/LBpU42Hy3H - htt…
RT @WorldUnivAndSch: reversing aging in dogs and mice evidence https://t.co/GDdOKZbz0u - https://t.co/SCW1ReQ8qb - https://t.co/pzKN2aPJbS…
RT @WUaSPress: reversing aging in dogs and mice evidence https://t.co/pPRPbLjHm8 - https://t.co/QKRd7iZH90 - https://t.co/7x9OMxzZEY - http…
RT @scottmacleod: reversing aging in dogs and mice evidence https://t.co/pFXuAsFaoF - https://t.co/btJQZxLAKk - https://t.co/ixucHv8WTA - h…
RT @HarbinBook: reversing aging in dogs and mice evidence https://t.co/pD9RyqWIFn - https://t.co/6gqnTc2kJ7 - https://t.co/vHUJK9fsgU - htt…
RT @HarbinBook: reversing aging in dogs and mice evidence https://t.co/pD9RyqWIFn - https://t.co/6gqnTc2kJ7 - https://t.co/vHUJK9fsgU - htt…
RT @WorldUnivAndSch: reversing aging in dogs and mice evidence https://t.co/GDdOKZbz0u - https://t.co/SCW1ReQ8qb - https://t.co/pzKN2aPJbS…
RT @HarbinBook: reversing aging in dogs and mice evidence https://t.co/pD9RyqWIFn - https://t.co/6gqnTc2kJ7 - https://t.co/vHUJK9fsgU - htt…
RT @scottmacleod: reversing aging in dogs and mice evidence https://t.co/pFXuAsFaoF - https://t.co/btJQZxLAKk - https://t.co/ixucHv8WTA - h…
RT @WorldUnivAndSch: reversing aging in dogs and mice evidence https://t.co/GDdOKZbz0u - https://t.co/SCW1ReQ8qb - https://t.co/pzKN2aPJbS…
RT @WorldUnivAndSch: reversing aging in dogs and mice evidence https://t.co/GDdOKZbz0u - https://t.co/SCW1ReQ8qb - https://t.co/pzKN2aPJbS…
RT @scottmacleod: reversing aging in dogs and mice evidence https://t.co/pFXuAsFaoF - https://t.co/btJQZxLAKk - https://t.co/ixucHv8WTA - h…
RT @WorldUnivAndSch: reversing aging in dogs and mice evidence https://t.co/GDdOKZbz0u - https://t.co/SCW1ReQ8qb - https://t.co/pzKN2aPJbS…
RT @WorldUnivAndSch: reversing aging in dogs and mice evidence https://t.co/GDdOKZbz0u - https://t.co/SCW1ReQ8qb - https://t.co/pzKN2aPJbS…
RT @scottmacleod: reversing aging in dogs and mice evidence https://t.co/pFXuAsFaoF - https://t.co/btJQZxLAKk - https://t.co/ixucHv8WTA - h…
RT @HarbinBook: reversing aging in dogs and mice evidence https://t.co/pD9RyqWIFn - https://t.co/6gqnTc2kJ7 - https://t.co/vHUJK9fsgU - htt…
RT @WUaSPress: reversing aging in dogs and mice evidence https://t.co/pPRPbLjHm8 - https://t.co/QKRd7iZH90 - https://t.co/7x9OMxzZEY - http…
RT @scottmacleod: reversing aging in dogs and mice evidence https://t.co/pFXuAsFaoF - https://t.co/btJQZxLAKk - https://t.co/ixucHv8WTA - h…
RT @sgkmacleod: reversing aging in dogs and mice evidence https://t.co/Ebqc7ietK4 - https://t.co/loNUGSuFJF - https://t.co/LBpU42Hy3H - htt…
reversing aging in dogs and mice evidence https://t.co/pD9RyqWIFn - https://t.co/6gqnTc2kJ7 - https://t.co/vHUJK9fsgU - https://t.co/FOffZrdeQ5 - https://t.co/9QYf8Qg8Q1 - https://t.co/PjijdXPVzd - https://t.co/WwmdGxD82H > https://t.co/rZk6BuWycH ~ @Wo
reversing aging in dogs and mice evidence https://t.co/Ebqc7ietK4 - https://t.co/loNUGSuFJF - https://t.co/LBpU42Hy3H - https://t.co/Z4t5Yd8BOn - https://t.co/5ChPdvLCOh - https://t.co/eJ6fTaoBdg - https://t.co/FlNqQjhV2b > https://t.co/jR50v29WBk ~ @Wo
reversing aging in dogs and mice evidence https://t.co/pFXuAsFaoF - https://t.co/btJQZxLAKk - https://t.co/ixucHv8WTA - https://t.co/pnTWuyroXm - https://t.co/Cx6mlxYbcR - https://t.co/02jzjh1Cjo - https://t.co/3QRqGAqBkz > https://t.co/sUN5ZWQuAC ~ @Wo
reversing aging in dogs and mice evidence https://t.co/pPRPbLjHm8 - https://t.co/QKRd7iZH90 - https://t.co/7x9OMxzZEY - https://t.co/Yqxre6UYPO - https://t.co/QcEZt5KQ7D - https://t.co/hxcHUeAiZf - https://t.co/7QI3ouaHNh > https://t.co/Wx2RA7XtUX ~ @Wo
reversing aging in dogs and mice evidence https://t.co/GDdOKZbz0u - https://t.co/SCW1ReQ8qb - https://t.co/pzKN2aPJbS - https://t.co/6IcongpaIE - https://t.co/ztzrZqjFNW - https://t.co/dZH2wiSamm - https://t.co/giTmHNO1IQ > https://t.co/dRISYwajP4 ~ @Wo
RT @GeriSciDoc: Serious fun: The Dog Aging Project and TOR/rapamycin: https://t.co/3GZQGMMLhg https://t.co/W1NcjxDtIR #LifeStagesGerosci
Serious fun: The Dog Aging Project and TOR/rapamycin: https://t.co/3GZQGMMLhg https://t.co/W1NcjxDtIR #LifeStagesGerosci
Health: rapamycin 0.5mg/kg or 1mg/kg in dogs, 3x per week, improve (="rejuvenated") cardiac function in dogs. Analysis: similar effects are possible with a 3x a week low protein regiment. TOOLs? To expolore. https://t.co/r3Mvn454mq https://t.co/ka8ktcd2dt
RT @mkaeberlein: @dogagingproject Phase I rapamycin trial just published in GeroScience. #springerlink https://t.co/5c3Erw1Zsf
RT @Mangan150: Rapamycin given to dogs for 10 weeks resulted in no side effects and possible improvement in heart function. https://t.co/F…
Rapamycin given to dogs for 10 weeks resulted in no side effects and possible improvement in heart function. https://t.co/FsXAVWEq1K
Serious fun: The Dog Aging Project and TOR/rapamycin: https://t.co/3GZQGMMLhg https://t.co/W1NcjxDtIR #LifeStagesGerosci
RT @mkaeberlein: @dogagingproject Phase I rapamycin trial just published in GeroScience. #springerlink https://t.co/5c3Erw1Zsf
RT @mkaeberlein: @dogagingproject Phase I rapamycin trial just published in GeroScience. #springerlink https://t.co/5c3Erw1Zsf
Rapamycin treatment in aged dogs could improve both diastolic and systolic age-related measures of #heart_function https://t.co/QIlqI8DCN1
RT @mkaeberlein: @dogagingproject Phase I rapamycin trial just published in GeroScience. #springerlink https://t.co/5c3Erw1Zsf
Conclusion To summarize, this initial study of rapamycin in healthy, middle-aged dogs showed that low-dose... https://t.co/Frtvh7wExc
@TODAYshow article is here: https://t.co/BsUnJ0GcBl
RT @mkaeberlein: @dogagingproject Phase I rapamycin trial just published in GeroScience. #springerlink https://t.co/5c3Erw1Zsf
RT @mkaeberlein: @dogagingproject Phase I rapamycin trial just published in GeroScience. #springerlink https://t.co/5c3Erw1Zsf
@americanaging Phase I rapamycin trial https://t.co/BsUnJ0GcBl just published in GeroScience https://t.co/2lkSMd3MP0.
RT @mkaeberlein: @dogagingproject Phase I rapamycin trial just published in GeroScience. #springerlink https://t.co/5c3Erw1Zsf
@NABRorg Latest Article: https://t.co/BsUnJ0GcBl #aging #dogs #rapamycin
Dogs Test Drug Aimed at Humans’ Biggest Killer: Age https://t.co/qNwm444BRx Article: https://t.co/BsUnJ0GcBl #aging #dogs #rapamycin
RT @mkaeberlein: @dogagingproject Phase I rapamycin trial just published in GeroScience. #springerlink https://t.co/5c3Erw1Zsf
RT @mkaeberlein: @dogagingproject Phase I rapamycin trial just published in GeroScience. #springerlink https://t.co/5c3Erw1Zsf
RT @mkaeberlein: @dogagingproject Phase I rapamycin trial just published in GeroScience. #springerlink https://t.co/5c3Erw1Zsf
RT @mkaeberlein: @dogagingproject Phase I rapamycin trial just published in GeroScience. #springerlink https://t.co/5c3Erw1Zsf
New @DogAgingProject paper: 10 weeks of #rapamycin in dogs didn't cause side effects and improved heart function. https://t.co/0N89N1Udej
RT @mkaeberlein: @dogagingproject Phase I rapamycin trial just published in GeroScience. #springerlink https://t.co/5c3Erw1Zsf
RT @mkaeberlein: @dogagingproject Phase I rapamycin trial just published in GeroScience. #springerlink https://t.co/5c3Erw1Zsf
RT @mkaeberlein: @dogagingproject Phase I rapamycin trial just published in GeroScience. #springerlink https://t.co/5c3Erw1Zsf