| Title |
MELK—a conserved kinase: functions, signaling, cancer, and controversy
|
|---|---|
| Published in |
Clinical and Translational Medicine, March 2015
|
| DOI | 10.1186/s40169-014-0045-y |
| Pubmed ID | |
| Authors |
Ranjit Ganguly, Ahmed Mohyeldin, Jordyn Thiel, Harley I Kornblum, Monique Beullens, Ichiro Nakano |
| Abstract |
Maternal embryonic leucine zipper kinase (MELK) is a highly conserved serine/threonine kinase initially found to be expressed in a wide range of early embryonic cellular stages, and as a result has been implicated in embryogenesis and cell cycle control. Recent evidence has identified a broader spectrum of tissue expression pattern for this kinase than previously appreciated. MELK is expressed in several human cancers and stem cell populations. Unique spatial and temporal patterns of expression within these tissues suggest that MELK plays a prominent role in cell cycle control, cell proliferation, apoptosis, cell migration, cell renewal, embryogenesis, oncogenesis, and cancer treatment resistance and recurrence. These findings have important implications for our understanding of development, disease, and cancer therapeutics. Furthermore understanding MELK signaling may elucidate an added dimension of stem cell control. |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Unknown | 97 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 32% |
| Researcher | 18 | 18% |
| Student > Bachelor | 17 | 17% |
| Student > Master | 10 | 10% |
| Student > Doctoral Student | 3 | 3% |
| Other | 8 | 8% |
| Unknown | 11 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 33 | 34% |
| Agricultural and Biological Sciences | 23 | 23% |
| Medicine and Dentistry | 10 | 10% |
| Neuroscience | 4 | 4% |
| Chemistry | 4 | 4% |
| Other | 6 | 6% |
| Unknown | 18 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2017.
All research outputs
#6,598,118
of 25,374,917 outputs
Outputs from Clinical and Translational Medicine
#257
of 1,060 outputs
Outputs of similar age
#70,394
of 273,966 outputs
Outputs of similar age from Clinical and Translational Medicine
#3
of 11 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 1,060 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.2. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,966 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.