Title |
Lower CD28+ T cell proportions were associated with CMV-seropositivity in patients with Hashimoto’s thyroiditis
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Published in |
BMC Endocrine Disorders, September 2013
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DOI | 10.1186/1472-6823-13-34 |
Pubmed ID | |
Authors |
Martina Prelog, Jörn Schönlaub, Reinhard Würzner, Christian Koppelstaetter, Giovanni Almanzar, Andrea Brunner, Martin Gasser, Rupert Prommegger, Gabriele Häusler, Klaus Kapelari, Wolfgang Högler |
Abstract |
Alterations in the naive T cell subpopulations have been demonstrated in patients with T cell mediated autoimmune disorders, reminiscent of immunological changes found in the elderly during immunosenescence, including the switch from CD45RA + to CD45RO + T cells and decreased thymic function with increased compensatory proliferative mechanisms, partly associated with latent Cytomegalovirus (CMV) infection. The present study was aimed to investigate proportions of lymphocytes, their relation to CMV-seropositivity and the replicative history of CD45RA + expressing T cells in Hashimoto's thyroiditis (HT, n = 18) and healthy controls (HC, n = 70). |
X Demographics
Geographical breakdown
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 24% |
Researcher | 3 | 18% |
Student > Doctoral Student | 2 | 12% |
Student > Bachelor | 1 | 6% |
Student > Master | 1 | 6% |
Other | 1 | 6% |
Unknown | 5 | 29% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 24% |
Biochemistry, Genetics and Molecular Biology | 2 | 12% |
Agricultural and Biological Sciences | 2 | 12% |
Immunology and Microbiology | 2 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Other | 0 | 0% |
Unknown | 6 | 35% |