Title |
Traffic, asthma and genetics: combining international birth cohort data to examine genetics as a mediator of traffic-related air pollution’s impact on childhood asthma
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Published in |
European Journal of Epidemiology, July 2013
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DOI | 10.1007/s10654-013-9828-5 |
Pubmed ID | |
Authors |
Elaina A. MacIntyre, Christopher Carlsten, Meaghan MacNutt, Elaine Fuertes, Eric Melén, Carla M. T. Tiesler, Ulrike Gehring, Ursula Krämer, Claudia Klümper, Marjan Kerkhof, Moira Chan-Yeung, Anita L. Kozyrskyj, Dietrich Berdel, Carl Peter Bauer, Olf Herbarth, Mario Bauer, Beate Schaaf, Sibylle Koletzko, Goran Pershagen, Bert Brunekreef, Joachim Heinrich, Michael Brauer |
Abstract |
Associations between traffic-related air pollution and incident childhood asthma can be strengthened by analysis of gene-environment interactions, but studies have typically been limited by lack of study power. We combined data from six birth cohorts on: asthma, eczema and allergic rhinitis to 7/8 years, and candidate genes. Individual-level assessment of traffic-related air pollution exposure was estimated using land use regression or dispersion modeling. A total of 11,760 children were included in the Traffic, Asthma and Genetics (TAG) Study; 6.3 % reported physician-diagnosed asthma at school-age, 16.0 % had asthma at anytime during childhood, 14.1 % had allergic rhinitis at school-age, 10.0 % had eczema at school-age and 33.1 % were sensitized to any allergen. For GSTP1 rs1138272, the prevalence of heterozygosity was 16 % (range amongst individual cohorts, 11-17 %) and homozygosity for the minor allele was 1 % (0-2 %). For GSTP1 rs1695, the prevalence of heterozygosity was 45 % (40-48 %) and homozygosity for the minor allele, 12 % (10-12 %). For TNF rs1800629, the prevalence of heterozygosity was 29 % (25-32 %) and homozygosity for the minor allele, 3 % (1-3 %). TAG comprises a rich database, the largest of its kind, for investigating the effect of genotype on the association between air pollution and childhood allergic disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 17% |
Canada | 1 | 8% |
Argentina | 1 | 8% |
Ireland | 1 | 8% |
Unknown | 7 | 58% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 11 | 92% |
Scientists | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 1% |
France | 1 | 1% |
Unknown | 67 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 11 | 16% |
Researcher | 10 | 14% |
Student > Ph. D. Student | 6 | 9% |
Student > Doctoral Student | 6 | 9% |
Student > Bachelor | 6 | 9% |
Other | 15 | 22% |
Unknown | 15 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 25% |
Environmental Science | 12 | 17% |
Agricultural and Biological Sciences | 9 | 13% |
Biochemistry, Genetics and Molecular Biology | 3 | 4% |
Computer Science | 2 | 3% |
Other | 5 | 7% |
Unknown | 21 | 30% |