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Differential Methylation of Imprinted Genes in Growth-Restricted Placentas

Overview of attention for article published in Reproductive Sciences, June 2011
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Title
Differential Methylation of Imprinted Genes in Growth-Restricted Placentas
Published in
Reproductive Sciences, June 2011
DOI 10.1177/1933719111404611
Pubmed ID
Authors

Luca Lambertini, Tin-Lap Lee, Wai-Yee Chan, Men-Jean Lee, Andreas Diplas, James Wetmur, Jia Chen

Abstract

A complex network of epigenetic factors participates in regulating the monoallelic expression of a small subset of genes (~1%) in the human genome. This phenomenon goes under the definition of genomic imprinting, a parent-of-origin effect that, when altered during early embryogenesis, may influence fetal development into adulthood. Pertubations in genomic imprinting have been associated with placental and fetal growth restrictions. We analyzed the differential DNA methylation of all known imprinted genes on 10 appropriate-for-gestational-age, clinically normal, placentas and 7 severe intrauterine growth-restricted placentas. Samples were pooled according to the diagnosis and analyzed by methylated DNA immunoprecipitation (MeDIP) on a tiling microarray platform. The distribution of the differentially methylated regions (DMRs) identified in growth-restricted placentas showed a slight tendency toward hypermethylation. Imprinted genes not expressed in placenta showed a unique DMR profile with the fewest hyper- and hypomethylated DMRs. Promoter and CpG island DMRs were sporadic and randomly distributed. The vast majority of DMR identified (~99%) were mapped in introns, showing no common sequence features. Also, by using the more advanced array data mining softwares, no significant patterns emerged. In contrast, differential methylation showed a highly significant correlation with gene length. Overall these data suggest that differential methylation changes in growth-restricted placentas occur throughout the genomic regions, encompassing genes actively expressed in the placenta. These findings warrant caution in interpreting the significance of genes carrying clustered DMRs because the distribution of DMRs in a gene may be attributed as a function of its length rather than as a specific biological role.

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Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 4%
Netherlands 1 2%
Brazil 1 2%
Unknown 46 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 30%
Researcher 8 16%
Student > Master 7 14%
Student > Bachelor 5 10%
Student > Doctoral Student 3 6%
Other 9 18%
Unknown 3 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 38%
Medicine and Dentistry 16 32%
Biochemistry, Genetics and Molecular Biology 4 8%
Psychology 2 4%
Environmental Science 1 2%
Other 5 10%
Unknown 3 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 July 2013.
All research outputs
#10,037,246
of 12,544,848 outputs
Outputs from Reproductive Sciences
#315
of 604 outputs
Outputs of similar age
#105,193
of 152,697 outputs
Outputs of similar age from Reproductive Sciences
#8
of 12 outputs
Altmetric has tracked 12,544,848 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 604 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 152,697 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.