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Assessment of human telomeric G-quadruplex structures using surface-enhanced Raman spectroscopy

Overview of attention for article published in Analytical & Bioanalytical Chemistry, January 2017
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Title
Assessment of human telomeric G-quadruplex structures using surface-enhanced Raman spectroscopy
Published in
Analytical & Bioanalytical Chemistry, January 2017
DOI 10.1007/s00216-016-0172-y
Pubmed ID
Authors

Snežana Miljanić, Marina Ratkaj, Marija Matković, Ivo Piantanida, Paola Gratteri, Carla Bazzicalupi

Abstract

G-Quadruplex (G4) structures of a human telomeric 24-mer (5'-TTAGGGTTAGGGTTAGGGTTAGGG-3') sequence (Tel24) stabilized by sodium and potassium ions have been assessed using surface-enhanced Raman scattering (SERS) spectroscopy. The distinctive SERS spectra of Tel24 in the presence of 100 mM Na(+) and 100 mM K(+) were obtained and the SERS bands characteristic of the antiparallel basket-type and the mixed hybrid (3+1) structures, respectively, were identified and assigned. The influence of the SERS - active substrate on the scattering enhancement was studied using citrate- and chloride-covered silver nanoparticles, in the absence and presence of the aggregating agent (0.1 M Na2SO4 and 0.1 M K2SO4). The highly reproducible SERS spectra of Tel24 obtained in various SERS active media indicated the same adsorption mechanism of the cation - stabilized G-quadruplexes onto the metal surface, regardless of the silver colloid. The remarkable resemblance between the circular dichroism (CD) spectra of the Tel24 structures with and without the colloid confirmed that interaction with the enhancing silver surface did not affect the stability of the formed G4 structures. The presented study pointed to a great potential of the SERS spectroscopy for the sensitive structural analysis of various G4 topologies. Graphical Abstract SERS spectroscopy allowed identification of Na(+) stabilized antiparallel basket-type and K(+) stabilized hybrid (3+1) structures of the same 24-mer human telomeric sequence.

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Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 25%
Unspecified 3 19%
Researcher 3 19%
Student > Doctoral Student 2 13%
Professor > Associate Professor 2 13%
Other 2 13%
Readers by discipline Count As %
Chemistry 8 50%
Unspecified 3 19%
Agricultural and Biological Sciences 2 13%
Materials Science 2 13%
Biochemistry, Genetics and Molecular Biology 1 6%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2017.
All research outputs
#7,028,783
of 9,222,312 outputs
Outputs from Analytical & Bioanalytical Chemistry
#1,573
of 3,141 outputs
Outputs of similar age
#225,345
of 315,292 outputs
Outputs of similar age from Analytical & Bioanalytical Chemistry
#63
of 160 outputs
Altmetric has tracked 9,222,312 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,141 research outputs from this source. They receive a mean Attention Score of 1.9. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,292 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 160 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.