| Title |
Transcriptome and metabolome analysis of liver and kidneys of rats chronically fed NK603 Roundup-tolerant genetically modified maize
|
|---|---|
| Published in |
Environmental Sciences Europe, February 2017
|
| DOI | 10.1186/s12302-017-0105-1 |
| Pubmed ID | |
| Authors |
Robin Mesnage, Matthew Arno, Gilles-Eric Séralini, Michael N. Antoniou |
| Abstract |
A previous 2-year rat feeding trial assessing potential toxicity of NK603 Roundup-tolerant genetically modified maize revealed blood and urine biochemical changes indicative of liver and kidney pathology. In an effort to obtain deeper insight into these findings, molecular profiling of the liver and kidneys from the same animals was undertaken. Transcriptomics showed no segregation of NK603 maize and control feed groups with false discovery rates ranging from 43 to 83% at a cut-off p value of 1%. Changes in gene expression were not reflective of liver and kidney toxic effects. Metabolomics identified 692 and 673 metabolites in kidney and liver, respectively. None of the statistically significant disturbances detected (12-56 for different test groups) survived a false discovery rate analysis. Differences in these metabolites between individual animals within a group were greater than the effect of test diets, which prevents a definitive conclusion on either pathology or safety. Even if the biological relevance of the statistical differences presented in this study is unclear, our results are made available for scrutiny by the scientific community and for comparison in future studies investigating potential toxicological properties of the NK603 corn. |
X Demographics
The data shown below were collected from the profiles of 34 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 21% |
| France | 3 | 9% |
| Côte d'Ivoire | 1 | 3% |
| Germany | 1 | 3% |
| Kenya | 1 | 3% |
| Madagascar | 1 | 3% |
| Switzerland | 1 | 3% |
| Belgium | 1 | 3% |
| Australia | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 16 | 47% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 30 | 88% |
| Scientists | 3 | 9% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 46 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 17% |
| Student > Bachelor | 5 | 11% |
| Student > Master | 4 | 9% |
| Student > Doctoral Student | 3 | 7% |
| Professor | 3 | 7% |
| Other | 8 | 17% |
| Unknown | 15 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 20% |
| Medicine and Dentistry | 4 | 9% |
| Biochemistry, Genetics and Molecular Biology | 4 | 9% |
| Environmental Science | 3 | 7% |
| Engineering | 2 | 4% |
| Other | 6 | 13% |
| Unknown | 18 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 July 2019.
All research outputs
#1,727,533
of 25,392,205 outputs
Outputs from Environmental Sciences Europe
#97
of 597 outputs
Outputs of similar age
#34,588
of 418,683 outputs
Outputs of similar age from Environmental Sciences Europe
#4
of 10 outputs
Altmetric has tracked 25,392,205 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 597 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.1. This one has done well, scoring higher than 83% of its peers.
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