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American tertiary clinic-referred bipolar II disorder versus bipolar I disorder associated with hastened depressive recurrence

Overview of attention for article published in International Journal of Bipolar Disorders, January 2017
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Title
American tertiary clinic-referred bipolar II disorder versus bipolar I disorder associated with hastened depressive recurrence
Published in
International Journal of Bipolar Disorders, January 2017
DOI 10.1186/s40345-017-0072-x
Pubmed ID
Authors

Bernardo Dell’Osso, Saloni Shah, Dennis Do, Laura D. Yuen, Farnaz Hooshmand, Po W. Wang, Shefali Miller, Terence A. Ketter

Abstract

Bipolar disorder (BD) is a chronic, frequently comorbid condition characterized by high rates of mood episode recurrence and suicidality. Little is known about prospective longitudinal characterization of BD type II (BD II) versus type I (BD I) in relation to time to depressive recurrence and recovery from major depressive episode. We therefore assessed times to depressive recurrence/recovery in tertiary clinic-referred BD II versus I patients. Outpatients referred to Stanford BD Clinic during 2000-2011 were assessed with Systematic Treatment Enhancement Program for BD (STEP-BD) Affective Disorders Evaluation and with Clinical Monitoring Form during up to 2 years of naturalistic treatment. Prevalence and clinical correlates of bipolar subtype in recovered (euthymic ≥8 weeks) and depressed patients were assessed. Kaplan-Meier analyses assessed the relationships between bipolar subtype and longitudinal depressive severity, and Cox proportional hazard analyses assessed the potential mediators. BD II versus BD I was less common among 105 recovered (39.0 vs. 61.0%, p = 0.03) and more common among 153 depressed (61.4 vs. 38.6%, p = 0.006) patients. Among recovered patients, BD II was associated with 6/25 (24.0%) baseline unfavorable illness characteristics/mood symptoms/psychotropics and hastened depressive recurrence (p = 0.015). Among depressed patients, BD II was associated with 8/25 (33.0%) baseline unfavorable illness characteristics/mood symptoms/psychotropics, but only non-significantly associated with delayed depressive recovery. BD II versus BD I was significantly associated with current depression and hastened depressive recurrence, but only non-significantly associated with delayed depressive recovery. Research on bipolar subtype relationships with depressive recurrence/recovery is warranted to enhance clinical management of BD patients.

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Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 22%
Student > Postgraduate 4 10%
Student > Ph. D. Student 3 7%
Student > Master 3 7%
Researcher 2 5%
Other 7 17%
Unknown 13 32%
Readers by discipline Count As %
Medicine and Dentistry 11 27%
Psychology 7 17%
Neuroscience 2 5%
Nursing and Health Professions 2 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 2 5%
Unknown 16 39%