Title |
The association of glycogen synthase kinase-3beta (GSK-3β) gene polymorphism with kidney function in long-term lithium-treated bipolar patients
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Published in |
International Journal of Bipolar Disorders, June 2013
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DOI | 10.1186/2194-7511-1-8 |
Pubmed ID | |
Authors |
Janusz K Rybakowski, Maria Abramowicz, Aleksandra Szczepankiewicz, Michal Michalak, Joanna Hauser, Stanislaw Czekalski |
Abstract |
Most bipolar patients experience a reduction in urinary concentrating ability within a few weeks of starting lithium treatment. This phenomenon may be connected with the effect of lithium on the glycogen synthase kinase-3beta (GSK-3β) present in the renal tubules. The GSK-3β gene is located on chromosome 3q13 and possesses a functional -50 C/T polymorphism. In the present study, we estimated this polymorphism in a group of long-term lithium-treated patients and assessed its association with various parameters of kidney function, including novel markers of kidney injury such as serum neutrophil gelatinase-associated lipocalin (NGAL) and urinary beta2-microglobulin (β2-MG). |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 2 | 18% |
Student > Bachelor | 2 | 18% |
Unspecified | 1 | 9% |
Student > Ph. D. Student | 1 | 9% |
Professor > Associate Professor | 1 | 9% |
Other | 1 | 9% |
Unknown | 3 | 27% |
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Unspecified | 1 | 9% |
Neuroscience | 1 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 9% |
Unknown | 3 | 27% |