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The association of glycogen synthase kinase-3beta (GSK-3β) gene polymorphism with kidney function in long-term lithium-treated bipolar patients

Overview of attention for article published in International Journal of Bipolar Disorders, June 2013
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Title
The association of glycogen synthase kinase-3beta (GSK-3β) gene polymorphism with kidney function in long-term lithium-treated bipolar patients
Published in
International Journal of Bipolar Disorders, June 2013
DOI 10.1186/2194-7511-1-8
Pubmed ID
Authors

Janusz K Rybakowski, Maria Abramowicz, Aleksandra Szczepankiewicz, Michal Michalak, Joanna Hauser, Stanislaw Czekalski

Abstract

Most bipolar patients experience a reduction in urinary concentrating ability within a few weeks of starting lithium treatment. This phenomenon may be connected with the effect of lithium on the glycogen synthase kinase-3beta (GSK-3β) present in the renal tubules. The GSK-3β gene is located on chromosome 3q13 and possesses a functional -50 C/T polymorphism. In the present study, we estimated this polymorphism in a group of long-term lithium-treated patients and assessed its association with various parameters of kidney function, including novel markers of kidney injury such as serum neutrophil gelatinase-associated lipocalin (NGAL) and urinary beta2-microglobulin (β2-MG).

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Other 1 14%
Student > Bachelor 1 14%
Student > Ph. D. Student 1 14%
Professor > Associate Professor 1 14%
Student > Postgraduate 1 14%
Other 0 0%
Unknown 2 29%
Readers by discipline Count As %
Medicine and Dentistry 4 57%
Pharmacology, Toxicology and Pharmaceutical Science 1 14%
Unknown 2 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2013.
All research outputs
#2,905,165
of 3,627,916 outputs
Outputs from International Journal of Bipolar Disorders
#40
of 42 outputs
Outputs of similar age
#67,855
of 85,142 outputs
Outputs of similar age from International Journal of Bipolar Disorders
#1
of 1 outputs
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So far Altmetric has tracked 42 research outputs from this source. They receive a mean Attention Score of 2.7. This one scored the same or higher as 2 of them.
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