Title |
Glomerular diseases and cancer: evaluation of underlying malignancy
|
---|---|
Published in |
Journal of Nephrology, October 2015
|
DOI | 10.1007/s40620-015-0234-9 |
Pubmed ID | |
Authors |
Antonello Pani, Camillo Porta, Laura Cosmai, Patrizia Melis, Matteo Floris, Doloretta Piras, Maurizio Gallieni, Mitchell Rosner, Claudio Ponticelli |
Abstract |
Onconephrology is an emerging medical subspecialty focused on the numerous interconnections between cancer and kidney diseases. Patient with malignancies commonly experience kidney problems including acute kidney injury, tumor lysis syndrome, fluid and electrolyte disorders and chronic kidney disease, often as a consequence of the anti-cancer treatment. Conversely, a number of glomerulopathies, tubulopathies and vascular renal diseases can early signal the presence of an underlying cancer. Furthermore, the administration of immunosuppressive drugs, especially cytotoxic drugs and calcineurin inhibitors, may strongly impair the immune response increasing the risk of cancer. The objective of this review article is to: (i) discuss paraneoplastic glomerular disease, (ii) review cancer as an adverse effect of immunosuppressive agents used to treat glomerulopathies, and (iii) in the absence of international approved guidelines, propose a screening program based on expert opinion aimed at guiding nephrologists to early detect malignancies during their clinical practice. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 8 | 19% |
United States | 5 | 12% |
France | 2 | 5% |
Ecuador | 2 | 5% |
Saudi Arabia | 1 | 2% |
United Arab Emirates | 1 | 2% |
Venezuela, Bolivarian Republic of | 1 | 2% |
Iraq | 1 | 2% |
Italy | 1 | 2% |
Other | 6 | 14% |
Unknown | 14 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 25 | 60% |
Practitioners (doctors, other healthcare professionals) | 8 | 19% |
Scientists | 5 | 12% |
Science communicators (journalists, bloggers, editors) | 4 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 71 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Postgraduate | 9 | 13% |
Student > Bachelor | 8 | 11% |
Researcher | 6 | 8% |
Professor > Associate Professor | 6 | 8% |
Student > Doctoral Student | 5 | 7% |
Other | 17 | 24% |
Unknown | 20 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 39 | 55% |
Biochemistry, Genetics and Molecular Biology | 3 | 4% |
Unspecified | 2 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Social Sciences | 1 | 1% |
Other | 1 | 1% |
Unknown | 23 | 32% |