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Brief Report: Biochemical Correlates of Clinical Impairment in High Functioning Autism and Asperger’s Disorder

Overview of attention for article published in Journal of Autism & Developmental Disorders, February 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (78th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

Mentioned by

blogs
1 blog

Citations

dimensions_citation
16 Dimensions

Readers on

mendeley
76 Mendeley
Title
Brief Report: Biochemical Correlates of Clinical Impairment in High Functioning Autism and Asperger’s Disorder
Published in
Journal of Autism & Developmental Disorders, February 2009
DOI 10.1007/s10803-009-0707-6
Pubmed ID
Authors

Natalia M. Kleinhans, Todd Richards, Kurt E. Weaver, Olivia Liang, Geraldine Dawson, Elizabeth Aylward

Abstract

Amygdala dysfunction has been proposed as a critical contributor to social impairment in autism spectrum disorders (ASD). The current study investigated biochemical abnormalities in the amygdala in 20 high functioning adults with autistic disorder or Asperger's disorder and 19 typically developing adults matched on age and IQ. Magnetic resonance spectroscopy was used to measure N-acetyl aspartate (NAA), creatine/phosphocreatine (Cre), choline/choline containing compounds (Cho), and Myoinositol (mI) in the right and left amygdala. There were no significant between-group differences in any of the metabolites. However, NAA and Cre levels were significantly correlated to clinical ratings on the Autism Diagnostic Interview-Revised. This suggests that altered metabolite levels in the amygdala may be associated with a more severe early developmental course in ASD.

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
United Kingdom 2 3%
Germany 1 1%
Mexico 1 1%
Japan 1 1%
Costa Rica 1 1%
Unknown 68 89%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 20%
Researcher 11 14%
Student > Master 10 13%
Professor > Associate Professor 8 11%
Unspecified 6 8%
Other 26 34%
Readers by discipline Count As %
Psychology 24 32%
Medicine and Dentistry 19 25%
Unspecified 7 9%
Neuroscience 5 7%
Engineering 4 5%
Other 17 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2009.
All research outputs
#2,819,886
of 12,316,253 outputs
Outputs from Journal of Autism & Developmental Disorders
#1,296
of 3,051 outputs
Outputs of similar age
#30,685
of 144,018 outputs
Outputs of similar age from Journal of Autism & Developmental Disorders
#23
of 49 outputs
Altmetric has tracked 12,316,253 research outputs across all sources so far. Compared to these this one has done well and is in the 77th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,051 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 144,018 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.