Title |
Reduced Bone Cortical Thickness in Boys with Autism or Autism Spectrum Disorder
|
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Published in |
Journal of Autism and Developmental Disorders, September 2007
|
DOI | 10.1007/s10803-007-0453-6 |
Pubmed ID | |
Authors |
Mary L. Hediger, Lucinda J. England, Cynthia A. Molloy, Kai F. Yu, Patricia Manning-Courtney, James L. Mills |
Abstract |
Bone development, casein-free diet use, supplements, and medications were assessed for 75 boys with autism or autism spectrum disorder, ages 4-8 years. Second metacarpal bone cortical thickness (BCT), measured on hand-wrist radiographs, and % deviations in BCT from reference medians were derived. BCT increased with age, but % deviations evidenced a progressive fall-off (p = .02): +3.1 +/- 4.7%, -6.5 +/- 4.0%, -16.6 +/- 3.4%, -19.4 +/- 3.7%,-24.1 +/- 4.4%, at ages 4-8, respectively, adjusting for height. The 12% of the boys on casein-free diets had an overall % deviation of -18.9 +/- 3.7%, nearly twice that of boys on minimally restricted or unrestricted diets (-10.5 +/- 1.3%, p < .04), although even for boys on minimally restricted or unrestricted diets the % deviation was highly significant (p < .001). Our data suggest that the bone development of autistic boys should be monitored as part of routine care, especially if they are on casein-free diets. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Norway | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Colombia | 1 | <1% |
United States | 1 | <1% |
Denmark | 1 | <1% |
Unknown | 135 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 16 | 12% |
Researcher | 14 | 10% |
Other | 12 | 9% |
Student > Ph. D. Student | 12 | 9% |
Student > Master | 10 | 7% |
Other | 34 | 24% |
Unknown | 41 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 25 | 18% |
Agricultural and Biological Sciences | 13 | 9% |
Psychology | 11 | 8% |
Nursing and Health Professions | 9 | 6% |
Biochemistry, Genetics and Molecular Biology | 6 | 4% |
Other | 29 | 21% |
Unknown | 46 | 33% |