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The Clinical Potential of Ademetionine (S-Adenosylmethionine) in Neurological Disorders

Overview of attention for article published in Drugs, August 1994
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

policy
1 policy source
patent
9 patents

Citations

dimensions_citation
135 Dimensions

Readers on

mendeley
40 Mendeley
Title
The Clinical Potential of Ademetionine (S-Adenosylmethionine) in Neurological Disorders
Published in
Drugs, August 1994
DOI 10.2165/00003495-199448020-00002
Pubmed ID
Authors

Teodoro Bottiglieri, Keith Hyland, Edward H. Reynolds

Abstract

This review focuses on the biochemical and clinical aspects of methylation in neuropsychiatric disorders and the clinical potential of their treatment with ademetionine (S-adenosylmethionine; SAMe). SAMe is required in numerous transmethylation reactions involving nucleic acids, proteins, phospholipids, amines and other neurotransmitters. The synthesis of SAMe is intimately linked with folate and vitamin B12 (cyanocobalamin) metabolism, and deficiencies of both these vitamins have been found to reduce CNS SAMe concentrations. Both folate and vitamin B12 deficiency may cause similar neurological and psychiatric disturbances including depression, dementia, myelopathy and peripheral neuropathy. SAMe has a variety of pharmacological effects in the CNS, especially on monoamine neurotransmitter metabolism and receptor systems. SAMe has antidepressant properties, and preliminary studies indicate that it may improve cognitive function in patients with dementia. Treatment with methyl donors (betaine, methionine and SAMe) is associated with remyelination in patients with inborn errors of folate and C-1 (one-carbon) metabolism. These studies support a current theory that impaired methylation may occur by different mechanisms in several neurological and psychiatric disorders.

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 3%
United Kingdom 1 3%
Unknown 38 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 23%
Researcher 7 18%
Student > Ph. D. Student 5 13%
Professor 4 10%
Student > Doctoral Student 4 10%
Other 11 28%
Readers by discipline Count As %
Medicine and Dentistry 10 25%
Unspecified 6 15%
Agricultural and Biological Sciences 5 13%
Pharmacology, Toxicology and Pharmaceutical Science 5 13%
Neuroscience 5 13%
Other 9 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2017.
All research outputs
#1,241,668
of 11,296,984 outputs
Outputs from Drugs
#118
of 2,306 outputs
Outputs of similar age
#53,995
of 318,171 outputs
Outputs of similar age from Drugs
#3
of 32 outputs
Altmetric has tracked 11,296,984 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,306 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 318,171 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.