| Title |
The Clinical Frailty Scale for mortality prediction of old acutely admitted intensive care patients: a meta-analysis of individual patient-level data
|
|---|---|
| Published in |
Annals of Intensive Care, May 2023
|
| DOI | 10.1186/s13613-023-01132-x |
| Pubmed ID | |
| Authors |
Raphael Romano Bruno, Bernhard Wernly, Sean M. Bagshaw, Mark van den Boogaard, Jai N. Darvall, Lina De Geer, Pablo Ruiz de Gopegui Miguelena, Daren K. Heyland, David Hewitt, Aluko A. Hope, Emilie Langlais, Pascale Le Maguet, Carmel L. Montgomery, Dimitrios Papageorgiou, Philippe Seguin, Wytske W. Geense, J. Alberto Silva-Obregón, Georg Wolff, Amin Polzin, Lisa Dannenberg, Malte Kelm, Hans Flaatten, Michael Beil, Marcus Franz, Sigal Sviri, Susannah Leaver, Bertrand Guidet, Ariane Boumendil, Christian Jung |
| Abstract |
This large-scale analysis pools individual data about the Clinical Frailty Scale (CFS) to predict outcome in the intensive care unit (ICU). A systematic search identified all clinical trials that used the CFS in the ICU (PubMed searched until 24th June 2020). All patients who were electively admitted were excluded. The primary outcome was ICU mortality. Regression models were estimated on the complete data set, and for missing data, multiple imputations were utilised. Cox models were adjusted for age, sex, and illness acuity score (SOFA, SAPS II or APACHE II). 12 studies from 30 countries with anonymised individualised patient data were included (n = 23,989 patients). In the univariate analysis for all patients, being frail (CFS ≥ 5) was associated with an increased risk of ICU mortality, but not after adjustment. In older patients (≥ 65 years) there was an independent association with ICU mortality both in the complete case analysis (HR 1.34 (95% CI 1.25-1.44), p < 0.0001) and in the multiple imputation analysis (HR 1.35 (95% CI 1.26-1.45), p < 0.0001, adjusted for SOFA). In older patients, being vulnerable (CFS 4) alone did not significantly differ from being frail. After adjustment, a CFS of 4-5, 6, and ≥ 7 was associated with a significantly worse outcome compared to CFS of 1-3. Being frail is associated with a significantly increased risk for ICU mortality in older patients, while being vulnerable alone did not significantly differ. New Frailty categories might reflect its "continuum" better and predict ICU outcome more accurately. Open Science Framework (OSF: https://osf.io/8buwk/ ). |
X Demographics
The data shown below were collected from the profiles of 96 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 14 | 15% |
| Spain | 7 | 7% |
| Japan | 6 | 6% |
| Germany | 5 | 5% |
| Colombia | 4 | 4% |
| Argentina | 3 | 3% |
| France | 3 | 3% |
| Ecuador | 3 | 3% |
| Italy | 2 | 2% |
| Other | 10 | 10% |
| Unknown | 39 | 41% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 79 | 82% |
| Practitioners (doctors, other healthcare professionals) | 12 | 13% |
| Scientists | 4 | 4% |
| Science communicators (journalists, bloggers, editors) | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 10% |
| Other | 3 | 10% |
| Student > Master | 2 | 7% |
| Researcher | 2 | 7% |
| Lecturer > Senior Lecturer | 1 | 3% |
| Other | 4 | 14% |
| Unknown | 14 | 48% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 31% |
| Engineering | 2 | 7% |
| Economics, Econometrics and Finance | 1 | 3% |
| Neuroscience | 1 | 3% |
| Nursing and Health Professions | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 15 | 52% |
Attention Score in Context
This research output has an Altmetric Attention Score of 54. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2023.
All research outputs
#798,021
of 25,804,096 outputs
Outputs from Annals of Intensive Care
#82
of 1,217 outputs
Outputs of similar age
#17,162
of 410,667 outputs
Outputs of similar age from Annals of Intensive Care
#4
of 30 outputs
Altmetric has tracked 25,804,096 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,217 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one has done particularly well, scoring higher than 93% of its peers.
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We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.