| Title |
Spontaneous regression of advanced transverse colon cancer with deficient mismatch repair: a case report
|
|---|---|
| Published in |
Surgical Case Reports, April 2023
|
| DOI | 10.1186/s40792-023-01595-x |
| Pubmed ID | |
| Authors |
Shinnosuke Harata, Hiroki Takahashi, Nanako Ando, Akira Kato, Kaori Watanabe, Takeshi Yanagita, Takuya Suzuki, Hajime Ushigome, Kazuyoshi Shiga, Ryo Ogawa, Yoichi Matsuo, Akira Mitsui, Masahiro Kimura, Shuji Takiguchi |
| Abstract |
Spontaneous regression (SR) of cancer occurs in 1 in 60,000-100,000 patients. This phenomenon has been reported in almost all cancer types, most commonly neuroblastoma, renal cell carcinoma, malignant melanoma, and lymphoma/leukemia. However, SR in colorectal cancer (CRC) is extremely rare, particularly in advanced cases. Hence, this report describes a very rare case of spontaneous regression of advanced transverse colon cancer. A 76-year-old female with anemia was diagnosed with a type II well-differentiated adenocarcinoma in the middle transverse colon. Two months later, a second colonoscopy examination was performed for preoperative marking, and it revealed tumor shrinkage and a shift to type 0-IIc morphology. Endoscopic tattooing was then performed, followed by a laparoscopic partial resection of the transverse colon with D3 lymph node dissection. However, the resected specimen contained no tumor, and colonoscopy showed no tumor remnants in the remaining colon. Histopathological examination revealed mucosal regeneration and a mucus nodule in between the submucosal and muscular layers, with no cancer cells detected. Immunohistochemical analysis revealed the loss of MutL homolog 1 (MLH1) and postmeiotic segregation increased 2 (PMS2) expression in the cancer cells of biopsied specimens, suggesting deficient mismatch repair (dMMR). The patient continues to be followed up until 6 years postoperatively, and no recurrence has been observed. In this study, we also reviewed similar reported cases of spontaneous regression of cancer involving dMMR. This study presents a rare case of spontaneous regression of advanced transverse colon cancer wherein dMMR is strongly involved. However, further accumulation of similar cases is needed to elucidate this phenomenon and to develop new treatment strategies for CRC. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 80% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2023.
All research outputs
#13,730,660
of 23,662,553 outputs
Outputs from Surgical Case Reports
#45
of 517 outputs
Outputs of similar age
#87,111
of 223,783 outputs
Outputs of similar age from Surgical Case Reports
#2
of 10 outputs
Altmetric has tracked 23,662,553 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 517 research outputs from this source. They receive a mean Attention Score of 0.9. This one has done particularly well, scoring higher than 90% of its peers.
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We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 8 of them.