Title |
The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia
|
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Published in |
Acta Neuropathologica, July 2010
|
DOI | 10.1007/s00401-010-0718-6 |
Pubmed ID | |
Authors |
Costantino Iadecola |
Abstract |
There is increasing evidence that cerebrovascular dysfunction plays a role not only in vascular causes of cognitive impairment but also in Alzheimer's disease (AD). Vascular risk factors and AD impair the structure and function of cerebral blood vessels and associated cells (neurovascular unit), effects mediated by vascular oxidative stress and inflammation. Injury to the neurovascular unit alters cerebral blood flow regulation, depletes vascular reserves, disrupts the blood-brain barrier, and reduces the brain's repair potential, effects that amplify the brain dysfunction and damage exerted by incident ischemia and coexisting neurodegeneration. Clinical-pathological studies support the notion that vascular lesions aggravate the deleterious effects of AD pathology by reducing the threshold for cognitive impairment and accelerating the pace of the dementia. In the absence of mechanism-based approaches to counteract cognitive dysfunction, targeting vascular risk factors and improving cerebrovascular health offers the opportunity to mitigate the impact of one of the most disabling human afflictions. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | 1% |
Italy | 3 | <1% |
Netherlands | 2 | <1% |
United States | 2 | <1% |
Canada | 2 | <1% |
India | 1 | <1% |
France | 1 | <1% |
Austria | 1 | <1% |
Unknown | 349 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 81 | 22% |
Researcher | 64 | 18% |
Student > Master | 46 | 13% |
Student > Bachelor | 31 | 8% |
Professor > Associate Professor | 25 | 7% |
Other | 60 | 16% |
Unknown | 58 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 89 | 24% |
Agricultural and Biological Sciences | 51 | 14% |
Neuroscience | 50 | 14% |
Biochemistry, Genetics and Molecular Biology | 22 | 6% |
Psychology | 21 | 6% |
Other | 54 | 15% |
Unknown | 78 | 21% |