| Title |
A fabricated hydrogel of hyaluronic acid/curcumin shows super-activity to heal the bacterial infected wound
|
|---|---|
| Published in |
AMB Express, March 2023
|
| DOI | 10.1186/s13568-023-01533-y |
| Pubmed ID | |
| Authors |
Maryam Khaleghi, Fakhri Haghi, Mina Gholami, Hamdam Hourfar, Farshad Shahi, Ali Mir Mousavi Zekoloujeh, Farhang Aliakbari, Ebrahim Ahmadi, Dina Morshedi |
| Abstract |
High risk of acute morbidities and even mortality from expanding the antibiotics resistant infectious wounds force indefinite efforts for development of high performance wound-healing materials. Herein, we design a procedure to fabricate a hyaluronic acid (HA)-based hydrogel to conjugate curcumin (Gel-H.P.Cur). The highlight of this work is to provide a favorite condition for capturing curcumin while protecting its structure and intensifying its activities because of the synchronization with HA. Accordingly, HA as a major component of dermis with a critical role in establishing skin health, could fortify the wound healing property as well as antibacterial activity of the hydrogel. Gel-H.P.Cur showed antibacterial properties against Pseudomonas aeruginosa (P. aeruginosa), which were examined by bactericidal efficiency, disk diffusion, anti-biofilm, and pyocyanin production assays. The effects of Gel-H.P.Cur on the inhibition of quorum sensing (QS) regulatory genes that contribute to expanding bacteria in the injured place was also significant. In addition, Gel-H.P.Cur showed high potential to heal the cutaneous wounds on the mouse excisional wound model with repairing histopathological damages rapidly and without scar. Taken together, the results strongly support Gel-H.P.Cur as a multipotent biomaterial for medical applications regarding the treatment of chronic, infected, and dehiscent wounds. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 27 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 3 | 11% |
| Student > Bachelor | 3 | 11% |
| Researcher | 2 | 7% |
| Other | 1 | 4% |
| Lecturer | 1 | 4% |
| Other | 4 | 15% |
| Unknown | 13 | 48% |
| Readers by discipline | Count | As % |
|---|---|---|
| Unspecified | 3 | 11% |
| Medicine and Dentistry | 3 | 11% |
| Engineering | 3 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
| Mathematics | 1 | 4% |
| Other | 2 | 7% |
| Unknown | 13 | 48% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2023.
All research outputs
#15,825,082
of 23,509,253 outputs
Outputs from AMB Express
#459
of 1,253 outputs
Outputs of similar age
#179,834
of 336,488 outputs
Outputs of similar age from AMB Express
#6
of 14 outputs
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So far Altmetric has tracked 1,253 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
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We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.