| Title |
Surgical resection of a retroperitoneal liposarcoma producing insulin-like growth factor II: a case report
|
|---|---|
| Published in |
Surgical Case Reports, February 2023
|
| DOI | 10.1186/s40792-023-01589-9 |
| Pubmed ID | |
| Authors |
Noriyuki Nishiwaki, Yoshihiro Mikuriya, Fumiaki Takatsu, Ryoji Ochiai, Tomokazu Kakishita, Naruyuki Kobayashi, Takaya Kobatake, Shinji Hato, Norihiro Teramoto, Mototsugu Nagao, Izumi Fukuda, Koji Ohta |
| Abstract |
Tumor-produced high molecular weight insulin-like growth factor-II (big insulin-like growth factor-II) is considered to cause non-islet cell tumor hypoglycemia. This paper presents a case of surgically resected retroperitoneal liposarcoma that produced big insulin-like growth factor-II. Here, we report the case of a 62-year-old woman who presented with an abdominal mass and hypoglycemia. Non-islet cell tumor hypoglycemia due to retroperitoneal liposarcoma was suspected. After complete resection of the tumor, the patient's hypoglycemia improved and big insulin-like growth factor-II disappeared in the molecular weight analysis of serum insulin-like growth factor-II by western blotting. The patient had no tumor recurrence or reappearance of hypoglycemia 16 months after the operation without any adjuvant therapy. Although insulin-like growth factor-II-producing tumors are generally large and difficult to operate on, surgical resection is currently the most effective and only treatment; thus, it is essential to attempt resection aggressively. |