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Immunohistochemical detection of early myocardial infarction: a systematic review

Overview of attention for article published in International Journal of Legal Medicine, November 2016
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Title
Immunohistochemical detection of early myocardial infarction: a systematic review
Published in
International Journal of Legal Medicine, November 2016
DOI 10.1007/s00414-016-1494-1
Pubmed ID
Authors

Cristina Mondello, Luigi Cardia, Elvira Ventura-Spagnolo

Abstract

The postmortem diagnosis of early myocardial infarction is a challenge for forensic pathologists because the routine histology is neither specific. Many authors have suggested the use of the immunohistochemistry to fill the gaps in the histological diagnosis of early myocardial infarction. This review aims to analyse advances of immunohistochemical detection of early cardiac damage due to ischaemia. To this purpose, we reviewed experimental studies that investigated immunohistochemical markers and their estimated timing of expression. The review was performed according to specific inclusion and exclusion criteria, and a total of 23 studies assessing the immunohistochemical markers for the diagnosis and timing of early myocardial infarction were identified. The literature review highlights that the analysed markers are complement components, others being inflammatory mediators, cardiac cell proteins, plasma proteins, stress or hypoxia-induced factors and proteins associated with heart failure. All studies demonstrate the effectiveness of the tested markers in the early detection of myocardial infarction in both animal and human samples.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 32%
Professor 4 21%
Student > Master 3 16%
Unspecified 3 16%
Student > Bachelor 1 5%
Other 2 11%
Readers by discipline Count As %
Medicine and Dentistry 15 79%
Unspecified 3 16%
Engineering 1 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2016.
All research outputs
#7,639,778
of 12,226,511 outputs
Outputs from International Journal of Legal Medicine
#587
of 1,049 outputs
Outputs of similar age
#183,335
of 336,875 outputs
Outputs of similar age from International Journal of Legal Medicine
#26
of 55 outputs
Altmetric has tracked 12,226,511 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,049 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 336,875 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.