| Title |
In vivo TSPO imaging in patients with multiple sclerosis: a brain PET study with [18F]FEDAA1106
|
|---|---|
| Published in |
EJNMMI Research, April 2013
|
| DOI | 10.1186/2191-219x-3-30 |
| Pubmed ID | |
| Authors |
Akihiro Takano, Fredrik Piehl, Jan Hillert, Andrea Varrone, Sangram Nag, Balázs Gulyás, Per Stenkrona, Victor L Villemagne, Christopher C Rowe, Richard Macdonell, Nabil Al Tawil, Thomas Kucinski, Torsten Zimmermann, Marcus Schultze-Mosgau, Andrea Thiele, Anja Hoffmann, Christer Halldin |
| Abstract |
The activation of microglia, in general, and the upregulation of the translocator protein (18 kDa) (TSPO) system, in particular, are key features of neuroinflammation, of which the in vivo visualization and quantitative assessment are still challenging due to the lack of appropriate molecular imaging biomarkers. Recent positron emission tomography (PET) studies using TSPO radioligands such as [11C]PK11195 and [11C]PBR28 have indicated the usefulness of these PET biomarkers in patients with neuroinflammatory diseases, including multiple sclerosis (MS). [18F]FEDAA1106 is a recently developed PET radioligand for the in vivo quantification of TSPO. In the present study, we aimed at investigating the diagnostic usefulness of [18F]FEDAA1106 in patients with MS. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 2% |
| Unknown | 50 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 37% |
| Student > Ph. D. Student | 10 | 20% |
| Student > Master | 5 | 10% |
| Student > Postgraduate | 3 | 6% |
| Student > Bachelor | 3 | 6% |
| Other | 6 | 12% |
| Unknown | 5 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 14 | 27% |
| Medicine and Dentistry | 12 | 24% |
| Chemistry | 4 | 8% |
| Agricultural and Biological Sciences | 4 | 8% |
| Immunology and Microbiology | 2 | 4% |
| Other | 9 | 18% |
| Unknown | 6 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 October 2019.
All research outputs
#8,262,107
of 25,374,647 outputs
Outputs from EJNMMI Research
#162
of 612 outputs
Outputs of similar age
#67,771
of 205,940 outputs
Outputs of similar age from EJNMMI Research
#3
of 17 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 612 research outputs from this source. They receive a mean Attention Score of 2.9. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 205,940 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.