Title |
Aims and structure of the German Research Consortium BipoLife for the study of bipolar disorder
|
---|---|
Published in |
International Journal of Bipolar Disorders, November 2016
|
DOI | 10.1186/s40345-016-0066-0 |
Pubmed ID | |
Authors |
Philipp S. Ritter, Felix Bermpohl, Oliver Gruber, Martin Hautzinger, Andreas Jansen, Georg Juckel, Tilo Kircher, Martin Lambert, Christoph Mulert, Andrea Pfennig, Andreas Reif, Otto Rienhoff, Thomas G. Schulze, Emanuel Severus, Thomas Stamm, Michael Bauer |
Abstract |
Bipolar disorder is a severe and heterogeneous mental disorder. Despite great advances in neuroscience over the past decades, the precise causative mechanisms at the transmitter, cellular or network level have so far not been unraveled. As a result, individual treatment decisions cannot be tailor-made and the uncertain prognosis is based on clinical characteristics alone. Although a subpopulation of patients have an excellent response to pharmacological monotherapy, other subpopulations have been less well served by the medical system and therefore require more focused attention. In particular individuals at high risk of bipolar disorder, young patients in the early stages of bipolar disorder, patients with an unstable highly relapsing course and patients with acute suicidal ideation have been identified as those in need. A research consortium of ten universities across Germany has therefore implemented a 4 year research agenda including three randomized controlled trials, one epidemiological trial and one cross-sectional trial to address these areas of unmet needs. The topics under investigation will be the improvement of early recognition, specific psychotherapy, and smartphones as an aid for early episode detection and biomarkers of lithium response. A subset of patients will be investigated utilizing neuroimaging (fMRI), neurophysiology (EEG), and biomaterials (genomics, transcriptomics). This article aims to outline the rationale, design, and methods of these individual studies. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 127 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 20 | 15% |
Researcher | 17 | 13% |
Student > Master | 15 | 12% |
Student > Bachelor | 12 | 9% |
Professor | 6 | 5% |
Other | 19 | 15% |
Unknown | 41 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 24 | 18% |
Medicine and Dentistry | 23 | 18% |
Neuroscience | 10 | 8% |
Computer Science | 7 | 5% |
Social Sciences | 5 | 4% |
Other | 18 | 14% |
Unknown | 43 | 33% |