Title |
Genome-wide linkage analyses of two repetitive behavior phenotypes in Utah pedigrees with autism spectrum disorders
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Published in |
Molecular Autism, February 2010
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DOI | 10.1186/2040-2392-1-3 |
Pubmed ID | |
Authors |
Dale S Cannon, Judith S Miller, Reid J Robison, Michele E Villalobos, Natalie K Wahmhoff, Kristina Allen-Brady, William M McMahon, Hilary Coon |
Abstract |
It has been suggested that efforts to identify genetic risk markers of autism spectrum disorder (ASD) would benefit from the analysis of more narrowly defined ASD phenotypes. Previous research indicates that 'insistence on sameness' (IS) and 'repetitive sensory-motor actions' (RSMA) are two factors within the ASD 'repetitive and stereotyped behavior' domain. The primary aim of this study was to identify genetic risk markers of both factors to allow comparison of those markers with one another and with markers found in the same set of pedigrees using ASD diagnosis as the phenotype. Thus, we empirically addresses the possibilities that more narrowly defined phenotypes improve linkage analysis signals and that different narrowly defined phenotypes are associated with different loci. Secondary aims were to examine the correlates of IS and RSMA and to assess the heritability of both scales. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 4% |
Netherlands | 1 | 2% |
Germany | 1 | 2% |
Unknown | 46 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 18% |
Student > Ph. D. Student | 8 | 16% |
Student > Master | 6 | 12% |
Professor | 5 | 10% |
Student > Postgraduate | 4 | 8% |
Other | 8 | 16% |
Unknown | 10 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 10 | 20% |
Agricultural and Biological Sciences | 9 | 18% |
Medicine and Dentistry | 6 | 12% |
Neuroscience | 4 | 8% |
Social Sciences | 2 | 4% |
Other | 6 | 12% |
Unknown | 13 | 26% |