Title |
Melatonin Versus Placebo in Children with Autism Spectrum Conditions and Severe Sleep Problems Not Amenable to Behaviour Management Strategies: A Randomised Controlled Crossover Trial
|
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Published in |
Journal of Autism and Developmental Disorders, June 2010
|
DOI | 10.1007/s10803-010-1036-5 |
Pubmed ID | |
Authors |
Barry Wright, David Sims, Siobhan Smart, Ahmed Alwazeer, Ben Alderson-Day, Victoria Allgar, Clare Whitton, Heather Tomlinson, Sophie Bennett, Jenni Jardine, Nicola McCaffrey, Charlotte Leyland, Christine Jakeman, Jeremy Miles |
Abstract |
Twenty-two children with autism spectrum disorders who had not responded to supported behaviour management strategies for severe dysomnias entered a double blind, randomised, controlled crossover trial involving 3 months of placebo versus 3 months of melatonin to a maximum dose of 10 mg. 17 children completed the study. There were no significant differences between sleep variables at baseline. Melatonin significantly improved sleep latency (by an average of 47 min) and total sleep (by an average of 52 min) compared to placebo, but not number of night wakenings. The side effect profile was low and not significantly different between the two arms. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | <1% |
France | 1 | <1% |
Australia | 1 | <1% |
Spain | 1 | <1% |
Japan | 1 | <1% |
United States | 1 | <1% |
Unknown | 229 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 33 | 14% |
Student > Ph. D. Student | 29 | 12% |
Researcher | 26 | 11% |
Student > Bachelor | 19 | 8% |
Other | 18 | 8% |
Other | 49 | 21% |
Unknown | 61 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 58 | 25% |
Psychology | 32 | 14% |
Agricultural and Biological Sciences | 15 | 6% |
Social Sciences | 13 | 6% |
Nursing and Health Professions | 9 | 4% |
Other | 35 | 15% |
Unknown | 73 | 31% |