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Dental implants in patients treated with antiresorptive medication – a systematic literature review

Overview of attention for article published in International Journal of Implant Dentistry, April 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (63rd percentile)

Mentioned by

1 policy source


53 Dimensions

Readers on

131 Mendeley
Dental implants in patients treated with antiresorptive medication – a systematic literature review
Published in
International Journal of Implant Dentistry, April 2016
DOI 10.1186/s40729-016-0041-7
Pubmed ID

Christian Walter, Bilal Al-Nawas, Tim Wolff, Eik Schiegnitz, Knut A. Grötz


Bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) is triggered by inflammatory processes. Typical trigger factors are periodontal disease, denture pressure sores, and surgical interventions such as tooth extractions. Unfortunately there is only little data on how to proceed with implant therapy in patients with bisphosphonate treatment. This topic is not addressed in the German guidelines on medication-associated osteonecrosis. Therefore a systematic literature review was performed. The PICO design was used: (Patients) For which subclientel of patients with antiresorptive therapy (intervention) do dental implants have a benefit (control) compared to forgoing dental implants (outcome) in regards to oral rehabilitation and quality of life without having a substantial risk of BP-ONJ development? A PubMed search was performed including all studies dealing with this topic. Case reports and studies with less than 5 cases were excluded. There is only very little data available, mostly retrospective case series. 50 articles were analyzed in detail. BP-ONJ can be triggered by dental implants and by dentures in patients with benign and malignant primary diseases. In most studies, analyzing osteoporosis patients only, no cases of BP-ONJ were observed in patients with implant therapy in the time span observed. There are no studies about implant therapy in patients with malignant diseases. Many case series analyzing the trigger factors for BP-ONJ describe dentures as one of the main causes. Perioperative antimicrobial prophylaxis has a benefit in the prevention of BP-ONJ development. Successful implant therapy is possible in patients receiving antiresorptive therapy. The possibility of osteonecrosis development needs to be explained to the patient. An individual risk assessment is essential, taking the primary disease with the medication and further wound-healing-compromising diseases and medications into account. If possible, bone augmentations should be avoided, and a perioperative antimicrobiological prophylaxis is strongly recommended in these patients.

Mendeley readers

The data shown below were compiled from readership statistics for 131 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
New Zealand 1 <1%
Unknown 130 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 17 13%
Student > Bachelor 13 10%
Student > Postgraduate 11 8%
Student > Ph. D. Student 10 8%
Student > Doctoral Student 9 7%
Other 29 22%
Unknown 42 32%
Readers by discipline Count As %
Medicine and Dentistry 73 56%
Veterinary Science and Veterinary Medicine 3 2%
Agricultural and Biological Sciences 3 2%
Chemical Engineering 1 <1%
Psychology 1 <1%
Other 7 5%
Unknown 43 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 July 2016.
All research outputs
of 8,156,965 outputs
Outputs from International Journal of Implant Dentistry
of 18 outputs
Outputs of similar age
of 240,286 outputs
Outputs of similar age from International Journal of Implant Dentistry
of 2 outputs
Altmetric has tracked 8,156,965 research outputs across all sources so far. This one has received more attention than most of these and is in the 60th percentile.
So far Altmetric has tracked 18 research outputs from this source. They receive a mean Attention Score of 1.5. This one scored the same or higher as 14 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,286 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them