| Title |
Type 1 diabetes mellitus and risk of incident epilepsy: a population-based, open-cohort study
|
|---|---|
| Published in |
Diabetologia, October 2016
|
| DOI | 10.1007/s00125-016-4142-x |
| Pubmed ID | |
| Authors |
George E. Dafoulas, Konstantinos A. Toulis, Dougall Mccorry, Balachadran Kumarendran, G. Neil Thomas, Brian H. Willis, Krishna Gokhale, George Gkoutos, Parth Narendran, Krishnarajah Nirantharakumar |
| Abstract |
The aim of this research was to explore the relationship between incident epilepsy and type 1 diabetes in British participants. Using The Health Improvement Network database, we conducted a retrospective, open-cohort study. Patients who were newly diagnosed with type 1 diabetes mellitus at the age of ≤40 years were identified and followed-up from 1 January 1990 to 15 September 2015. These patients, identified as not suffering from epilepsy at the time of diagnosis, were randomly matched with up to four individuals without type 1 diabetes mellitus, based on age, sex and participating general practice. A Cox regression analysis was subsequently performed using Townsend deprivation index, cerebral palsy, head injury and learning disabilities as model covariates. The study population consisted of a total of 24,610 individuals (4922 with type 1 diabetes and 19,688 controls). These individuals were followed up for a mean of 5.4 years (approximately 132,000 person-years of follow up). Patients with type 1 diabetes were significantly more likely to be diagnosed with epilepsy during the observation period compared with controls (crude HR [95% CI]: 3.02 [1.95, 4.69]). The incidence rate was estimated to be 132 and 44 per 100,000 person-years in patients and controls, respectively. This finding persisted after adjusting for model covariates (adjusted HR [95% CI]: 3.01 [1.93, 4.68]) and was also robust to sensitivity analysis, excluding adult-onset type 1 diabetes mellitus. Patients with type 1 diabetes are at approximately three-times greater risk of developing epilepsy compared with matched controls without type 1 diabetes. This should be considered when investigating seizure-related disorders in patients with type 1 diabetes mellitus. |
X Demographics
The data shown below were collected from the profiles of 31 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 23% |
| United Kingdom | 6 | 19% |
| Canada | 1 | 3% |
| Guatemala | 1 | 3% |
| United Arab Emirates | 1 | 3% |
| Germany | 1 | 3% |
| Greece | 1 | 3% |
| Unknown | 13 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 23 | 74% |
| Scientists | 4 | 13% |
| Practitioners (doctors, other healthcare professionals) | 4 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 98 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 16 | 16% |
| Researcher | 12 | 12% |
| Student > Ph. D. Student | 10 | 10% |
| Student > Master | 8 | 8% |
| Student > Postgraduate | 6 | 6% |
| Other | 22 | 22% |
| Unknown | 24 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 30% |
| Nursing and Health Professions | 7 | 7% |
| Neuroscience | 6 | 6% |
| Biochemistry, Genetics and Molecular Biology | 5 | 5% |
| Agricultural and Biological Sciences | 4 | 4% |
| Other | 15 | 15% |
| Unknown | 32 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 33. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2022.
All research outputs
#1,228,998
of 25,882,826 outputs
Outputs from Diabetologia
#647
of 5,396 outputs
Outputs of similar age
#22,076
of 320,298 outputs
Outputs of similar age from Diabetologia
#20
of 71 outputs
Altmetric has tracked 25,882,826 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,396 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.9. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,298 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.