| Title |
Risk factors for new-onset delirium in patients with bloodstream infections: independent and quantitative effect of catheters and drainages—a four-year cohort study
|
|---|---|
| Published in |
Annals of Intensive Care, October 2016
|
| DOI | 10.1186/s13613-016-0205-x |
| Pubmed ID | |
| Authors |
Tolga Dittrich, Sarah Tschudin-Sutter, Andreas F. Widmer, Stephan Rüegg, Stephan Marsch, Raoul Sutter |
| Abstract |
Bloodstream infections (BSI) and delirium are frequent in critically ill patients. During systemic inflammatory response to BSI, cytokines may interact with neurotransmitters and neuronal receptors driving acute brain dysfunction. However, prospectively collected data on incidence, prediction and impact of delirium in association with BSI are lacking. This study aimed to determine the incidence and predictors of new-onset delirium and its impact on outcome in critically ill adult patients with BSI. From 2011 to 2014, all consecutive adult patients with BSI treated in the intensive care units of an academic medical care center were identified. Pertinent clinical and microbiological data including the Intensive Care Delirium Screening Checklist (ICDSC) were assessed. Multivariable analysis was performed to identify variables independently associated with ICDSC ≥4. Among 240 patients, 145 (60%) had an ICDSC ≥4 (i.e., delirium). In-hospital mortality was 34%. Delirious patients had a higher mortality (40 vs. 23%; p = 0.005), a lower proportion with return to functional baseline (30 vs. 46%; p = 0.012), and a higher proportion with unfavorable outcome in survivors (74 vs. 54%; p = 0.010). Multivariable analyses revealed age (OR 1.04, 95% CI 1.02-1.06), male gender (OR 2.26, 95% CI 1.17-4.36), and the number of catheters and drainages before diagnosis of BSI (OR for every additional catheter = 1.14, 95% CI 1.04-1.25) as independent predictors for delirium (adjusted for SAPS [simplified acute physiology score] II, Riker Sedation-Agitation Scale [SAS], Sequential Organ Failure Assessment [SOFA] score, dementia and/or leukoencephalopathy, and albumin levels). The incidence of delirium in patients with BSI is high and associated with adverse outcome. The number of catheters and drainages may constitute a useful and readily available predictor of delirium in patients with BSI allowing to identify patients at high risk. Ultimately, reliable identification of patients at increased risk for delirium is key for allocation of specific prevention strategies. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 86 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 13 | 15% |
| Student > Ph. D. Student | 12 | 14% |
| Researcher | 6 | 7% |
| Student > Postgraduate | 5 | 6% |
| Student > Doctoral Student | 4 | 5% |
| Other | 21 | 24% |
| Unknown | 25 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 36 | 42% |
| Nursing and Health Professions | 8 | 9% |
| Psychology | 5 | 6% |
| Neuroscience | 3 | 3% |
| Computer Science | 3 | 3% |
| Other | 10 | 12% |
| Unknown | 21 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2020.
All research outputs
#2,954,420
of 22,896,955 outputs
Outputs from Annals of Intensive Care
#366
of 1,049 outputs
Outputs of similar age
#52,681
of 313,742 outputs
Outputs of similar age from Annals of Intensive Care
#2
of 26 outputs
Altmetric has tracked 22,896,955 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,049 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.8. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,742 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.