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Alzheimer’s disease in people with Down’s syndrome: the prospects for and the challenges of developing preventative treatments

Overview of attention for article published in Journal of Neurology, October 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

news
1 news outlet
twitter
1 X user
facebook
2 Facebook pages

Citations

dimensions_citation
46 Dimensions

Readers on

mendeley
160 Mendeley
Title
Alzheimer’s disease in people with Down’s syndrome: the prospects for and the challenges of developing preventative treatments
Published in
Journal of Neurology, October 2016
DOI 10.1007/s00415-016-8308-8
Pubmed ID
Authors

Paula Castro, Shahid Zaman, Anthony Holland

Abstract

People with Down's syndrome (DS) are at high risk for developing Alzheimer's disease (AD) at a relatively young age. This increased risk is not observed in people with intellectual disabilities for reasons other than DS and for this reason it is unlikely to be due to non-specific effects of having a neurodevelopmental disorder but, instead, a direct consequence of the genetics of DS (trisomy 21). Given the location of the amyloid precursor protein (APP) gene on chromosome 21, the amyloid cascade hypothesis is the dominant theory accounting for this risk, with other genetic and environmental factors modifying the age of onset and the course of the disease. Several potential therapies targeting the amyloid pathway and aiming to modify the course of AD are currently being investigated, which may also be useful for treating AD in DS. However, given that the neuropathology associated with AD starts many years before dementia manifests, any preventative treatment must start well before the onset of symptoms. To enable trials of such interventions, plasma, CSF, brain, and retinal biomarkers are being studied as proxy early diagnostic and outcome measures for AD. In this systematic review, we consider the prospects for the development of potential preventative treatments of AD in the DS population and their evaluation.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 160 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 <1%
Unknown 159 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 22 14%
Student > Ph. D. Student 20 13%
Student > Master 20 13%
Researcher 15 9%
Student > Doctoral Student 9 6%
Other 27 17%
Unknown 47 29%
Readers by discipline Count As %
Medicine and Dentistry 23 14%
Psychology 21 13%
Neuroscience 17 11%
Biochemistry, Genetics and Molecular Biology 12 8%
Nursing and Health Professions 9 6%
Other 28 18%
Unknown 50 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 October 2016.
All research outputs
#2,832,321
of 22,896,955 outputs
Outputs from Journal of Neurology
#582
of 4,487 outputs
Outputs of similar age
#50,462
of 313,854 outputs
Outputs of similar age from Journal of Neurology
#6
of 48 outputs
Altmetric has tracked 22,896,955 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,487 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,854 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.