Title |
Cannabinoid Receptor 2: Potential Role in Immunomodulation and Neuroinflammation
|
---|---|
Published in |
Journal of Neuroimmune Pharmacology, March 2013
|
DOI | 10.1007/s11481-013-9445-9 |
Pubmed ID | |
Authors |
Slava Rom, Yuri Persidsky |
Abstract |
An accumulating body of evidence suggests that endocannabinoids and cannabinoid receptors type 1 and 2 (CB(1), CB(2)) play a significant role in physiologic and pathologic processes, including cognitive and immune functions. While the addictive properties of marijuana, an extract from the Cannabis plant, are well recognized, there is growing appreciation of the therapeutic potential of cannabinoids in multiple pathologic conditions involving chronic inflammation (inflammatory bowel disease, arthritis, autoimmune disorders, multiple sclerosis, HIV-1 infection, stroke, Alzheimer's disease to name a few), mainly mediated by CB(2) activation. Development of CB(2) agonists as therapeutic agents has been hampered by the complexity of their intracellular signaling, relative paucity of highly selective compounds and insufficient data regarding end effects in the target cells and organs. This review attempts to summarize recent advances in studies of CB(2) activation in the setting of neuroinflammation, immunomodulation and HIV-1 infection. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 25% |
United Kingdom | 2 | 13% |
Netherlands | 1 | 6% |
Colombia | 1 | 6% |
Georgia | 1 | 6% |
Canada | 1 | 6% |
Unknown | 6 | 38% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 12 | 75% |
Scientists | 2 | 13% |
Practitioners (doctors, other healthcare professionals) | 2 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 1% |
Canada | 2 | <1% |
Germany | 1 | <1% |
United Kingdom | 1 | <1% |
Italy | 1 | <1% |
Spain | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 323 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 47 | 14% |
Student > Ph. D. Student | 45 | 13% |
Student > Bachelor | 44 | 13% |
Researcher | 41 | 12% |
Student > Postgraduate | 20 | 6% |
Other | 54 | 16% |
Unknown | 83 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 52 | 16% |
Agricultural and Biological Sciences | 33 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 33 | 10% |
Psychology | 27 | 8% |
Biochemistry, Genetics and Molecular Biology | 23 | 7% |
Other | 71 | 21% |
Unknown | 95 | 28% |