| Title |
Central Fatigue
|
|---|---|
| Published in |
Sports Medicine, November 2012
|
| DOI | 10.2165/00007256-200636100-00006 |
| Pubmed ID | |
| Authors |
Romain Meeusen, Philip Watson, Hiroshi Hasegawa, Bart Roelands, Maria F. Piacentini |
| Abstract |
The original central fatigue hypothesis suggested that an exercise-induced increase in extracellular serotonin concentrations in several brain regions contributed to the development of fatigue during prolonged exercise. Serotonin has been linked to fatigue because of its well known effects on sleep, lethargy and drowsiness and loss of motivation. Several nutritional and pharmacological studies have attempted to manipulate central serotonergic activity during exercise, but this work has yet to provide robust evidence for a significant role of serotonin in the fatigue process. However, it is important to note that brain function is not determined by a single neurotransmitter system and the interaction between brain serotonin and dopamine during prolonged exercise has also been explored as having a regulative role in the development of fatigue. This revised central fatigue hypothesis suggests that an increase in central ratio of serotonin to dopamine is associated with feelings of tiredness and lethargy, accelerating the onset of fatigue, whereas a low ratio favours improved performance through the maintenance of motivation and arousal. Convincing evidence for a role of dopamine in the development of fatigue comes from work investigating the physiological responses to amphetamine use, but other strategies to manipulate central catecholamines have yet to influence exercise capacity during exercise in temperate conditions. Recent findings have, however, provided support for a significant role of dopamine and noradrenaline (norepinephrine) in performance during exercise in the heat. As serotonergic and catecholaminergic projections innervate areas of the hypothalamus, the thermoregulatory centre, a change in the activity of these neurons may be expected to contribute to the control of body temperature whilst at rest and during exercise. Fatigue during prolonged exercise clearly is influenced by a complex interaction between peripheral and central factors. |
X Demographics
The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 13% |
| Vanuatu | 1 | 7% |
| Japan | 1 | 7% |
| Israel | 1 | 7% |
| Poland | 1 | 7% |
| Comoros | 1 | 7% |
| United States | 1 | 7% |
| Unknown | 7 | 47% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 87% |
| Scientists | 2 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 532 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 6 | 1% |
| Brazil | 4 | <1% |
| Malaysia | 2 | <1% |
| Canada | 2 | <1% |
| Portugal | 2 | <1% |
| Belgium | 2 | <1% |
| Spain | 2 | <1% |
| Sweden | 1 | <1% |
| New Zealand | 1 | <1% |
| Other | 3 | <1% |
| Unknown | 507 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 89 | 17% |
| Student > Bachelor | 88 | 17% |
| Student > Ph. D. Student | 84 | 16% |
| Researcher | 49 | 9% |
| Student > Postgraduate | 27 | 5% |
| Other | 97 | 18% |
| Unknown | 98 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Sports and Recreations | 188 | 35% |
| Medicine and Dentistry | 60 | 11% |
| Agricultural and Biological Sciences | 55 | 10% |
| Neuroscience | 25 | 5% |
| Nursing and Health Professions | 18 | 3% |
| Other | 66 | 12% |
| Unknown | 120 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 112. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2024.
All research outputs
#381,112
of 25,758,211 outputs
Outputs from Sports Medicine
#374
of 2,897 outputs
Outputs of similar age
#2,441
of 287,357 outputs
Outputs of similar age from Sports Medicine
#40
of 785 outputs
Altmetric has tracked 25,758,211 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,897 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.3. This one has done well, scoring higher than 87% of its peers.
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