| Title |
Phantom criteria for qualification of brain FDG and amyloid PET across different cameras
|
|---|---|
| Published in |
EJNMMI Physics, October 2016
|
| DOI | 10.1186/s40658-016-0159-y |
| Pubmed ID | |
| Authors |
Yasuhiko Ikari, Go Akamatsu, Tomoyuki Nishio, Kenji Ishii, Kengo Ito, Takeshi Iwatsubo, Michio Senda |
| Abstract |
While fluorodeoxyglucose (FDG) and amyloid PET is valuable for patient management, research, and clinical trial of therapeutics on Alzheimer's disease, the specific details of the PET scanning method including the PET camera model type influence the image quality, which may further affect the interpretation of images and quantitative capabilities. To make multicenter PET data reliable and to establish PET scanning as a universal diagnostic technique and a verified biomarker, we have proposed phantom test procedures and criteria for optimizing image quality across different PET cameras. As the method, four physical parameters (resolution, gray-white contrast, uniformity, and image noise) were selected as essential to image quality for brain FDG and amyloid PET and were measured with a Hoffman 3D brain phantom and a uniform cylindrical phantom on a total of 12 currently used PET models. The phantom radioactivity and acquisition time were determined based on the standard scanning protocol for each PET drug (FDG, (11)C-PiB, (18)F-florbetapir, and (18)F-flutemetamol). Reconstruction parameters were either determined based on the methods adopted in ADNI, J-ADNI, and other research and clinical trials or optimized based on measured phantom image parameters under various reconstruction conditions. As the result, phantom test criteria were proposed as follows: (i) 8 mm FWHM or better resolution and (ii) gray/white %contrast ≥55 % with the Hoffman 3D brain phantom and (iii) SD of 51 small region of interests (ROIs) ≤0.0249 (equivalent to 5 % variation) for uniformity and (iv) image noise (SD/mean) ≤15 % for a large ROI with the uniform cylindrical phantom. These criteria provided image quality conforming to those multicenter clinical studies and were also achievable with most of the PET cameras that are currently used. The proposed phantom test criteria facilitate standardization and qualification of brain FDG and amyloid PET images and deserve further evaluation by future multicenter clinical studies. |
Mendeley readers
The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 45 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 20% |
| Student > Ph. D. Student | 6 | 13% |
| Other | 5 | 11% |
| Student > Master | 3 | 7% |
| Librarian | 2 | 4% |
| Other | 7 | 16% |
| Unknown | 13 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 24% |
| Engineering | 6 | 13% |
| Nursing and Health Professions | 2 | 4% |
| Neuroscience | 2 | 4% |
| Physics and Astronomy | 2 | 4% |
| Other | 5 | 11% |
| Unknown | 17 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 October 2016.
All research outputs
#4,194,102
of 22,893,031 outputs
Outputs from EJNMMI Physics
#11
of 181 outputs
Outputs of similar age
#70,173
of 319,894 outputs
Outputs of similar age from EJNMMI Physics
#1
of 2 outputs
Altmetric has tracked 22,893,031 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 181 research outputs from this source. They receive a mean Attention Score of 2.6. This one has done well, scoring higher than 89% of its peers.
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