| Title |
Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management
|
|---|---|
| Published in |
SpringerPlus, February 2013
|
| DOI | 10.1186/2193-1801-2-56 |
| Pubmed ID | |
| Authors |
Yves Henrotin, Fabian Priem, Ali Mobasheri |
| Abstract |
The management of osteoarthritis represents a real challenge. This complex and multi-factorial disease evolves over decades and requires not only the alleviation of symptoms, i.e. pain and joint function but also the preservation of articular structure without side effects. Nutraceuticals are good candidates for the management of OA due to their safety profile and potential efficacy. However, they are not part of the treatment guidelines and published recommendations. Curcumin is the yellow pigment isolated from the rhizomes of Curcuma longa, commonly known as turmeric. Curcumin is a highly pleiotropic molecule with an excellent safety profile. Strong molecular evidence has been published for its potency to target multiple inflammatory diseases. However, naturally occurring curcumin cannot achieve its optimum therapeutic outcomes due to its low solubility and poor bioavailability. Nevertheless, curcumin presents great potential for treating OA and has been categorized as having preclinical evidence of efficacy. This review aimed at gathering most of the available information to document the potential efficacy of curcumin based on the results obtained in in vitro models of cartilage and osteoarthritis and in other diseases. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 57% |
| Australia | 1 | 14% |
| Germany | 1 | 14% |
| Unknown | 1 | 14% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 86% |
| Scientists | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 323 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Germany | 1 | <1% |
| Indonesia | 1 | <1% |
| Italy | 1 | <1% |
| United Kingdom | 1 | <1% |
| Russia | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 316 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 83 | 26% |
| Researcher | 40 | 12% |
| Student > Master | 39 | 12% |
| Student > Ph. D. Student | 26 | 8% |
| Other | 20 | 6% |
| Other | 53 | 16% |
| Unknown | 62 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 71 | 22% |
| Agricultural and Biological Sciences | 50 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 24 | 7% |
| Chemistry | 23 | 7% |
| Nursing and Health Professions | 22 | 7% |
| Other | 62 | 19% |
| Unknown | 71 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 47. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2022.
All research outputs
#884,606
of 25,382,035 outputs
Outputs from SpringerPlus
#32
of 1,873 outputs
Outputs of similar age
#5,992
of 204,051 outputs
Outputs of similar age from SpringerPlus
#3
of 112 outputs
Altmetric has tracked 25,382,035 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,873 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 204,051 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 112 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.