| Title |
Natural deep eutectic solvents: cytotoxic profile
|
|---|---|
| Published in |
SpringerPlus, June 2016
|
| DOI | 10.1186/s40064-016-2575-9 |
| Pubmed ID | |
| Authors |
Maan Hayyan, Yves Paul Mbous, Chung Yeng Looi, Won Fen Wong, Adeeb Hayyan, Zulhaziman Salleh, Ozair Mohd-Ali |
| Abstract |
The purpose of this study was to investigate the cytotoxic profiles of different ternary natural deep eutectic solvents (NADESs) containing water. For this purpose, five different NADESs were prepared using choline chloride as a salt, alongside five hydrogen bond donors (HBD) namely glucose, fructose, sucrose, glycerol, and malonic acid. Water was added as a tertiary component during the eutectics preparation, except for the malonic acid-based mixture. Coincidentally, the latter was found to be more toxic than any of the water-based NADESs. A trend was observed between the cellular requirements of cancer cells, the viscosity of the NADESs, and their cytotoxicity. This study also highlights the first time application of the conductor-like screening model for real solvent (COSMO-RS) software for the analysis of the cytotoxic mechanism of NADESs. COSMO-RS simulation of the interactions between NADESs and cellular membranes' phospholipids suggested that NADESs strongly interacted with cell surfaces and that their accumulation and aggregation possibly defined their cytotoxicity. This reinforced the idea that careful selection of NADESs components is necessary, as it becomes evident that organic acids as HBD highly contribute to the increasing toxicity of these neoteric mixtures. Nevertheless, NADESs in general seem to possess relatively less acute toxicity profiles than their DESs parents. This opens the door for future large scale utilization of these mixtures. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 316 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | <1% |
| Germany | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 313 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 55 | 17% |
| Student > Master | 46 | 15% |
| Researcher | 35 | 11% |
| Student > Bachelor | 26 | 8% |
| Professor | 13 | 4% |
| Other | 47 | 15% |
| Unknown | 94 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 70 | 22% |
| Agricultural and Biological Sciences | 28 | 9% |
| Engineering | 25 | 8% |
| Chemical Engineering | 24 | 8% |
| Biochemistry, Genetics and Molecular Biology | 17 | 5% |
| Other | 39 | 12% |
| Unknown | 113 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2016.
All research outputs
#18,531,724
of 22,953,506 outputs
Outputs from SpringerPlus
#1,266
of 1,852 outputs
Outputs of similar age
#268,013
of 352,470 outputs
Outputs of similar age from SpringerPlus
#163
of 230 outputs
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