| Title |
Mechanisms of chemoresistance in cancer stem cells
|
|---|---|
| Published in |
Clinical and Translational Medicine, January 2013
|
| DOI | 10.1186/2001-1326-2-3 |
| Pubmed ID | |
| Authors |
Lissa Nurrul Abdullah, Edward Kai-Hua Chow |
| Abstract |
Chemotherapy is one of the standard methods of treatment in many cancers. While chemotherapy is often capable of inducing cell death in tumors and reducing the tumor bulk, many cancer patients experience recurrence and ultimately death because of treatment failure. In recent years, cancer stem cells (CSCs) have gained intense interest as key tumor-initiating cells that may also play an integral role in recurrence following chemotherapy. As such, a number of mechanisms of chemoresistance have been identified in CSCs. In this review, we describe a number of these mechanisms of chemoresistance including ABC transporter expression, aldehyde dehydrogenase (ALDH) activity, B-cell lymphoma-2 (BCL2) related chemoresistance, enhanced DNA damage response and activation of key signaling pathways. Furthermore, we evaluate studies that demonstrate potential methods for overcoming chemoresistance and treating chemoresistant cancers that are driven by CSCs. By understanding how tumor-initiating cells such as CSCs escape chemotherapy, more informed approaches to treating cancer will develop and may improve clinical outcomes for cancer patients. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 25% |
| Italy | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 561 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| India | 2 | <1% |
| France | 1 | <1% |
| South Africa | 1 | <1% |
| Colombia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| Taiwan | 1 | <1% |
| Switzerland | 1 | <1% |
| Other | 4 | <1% |
| Unknown | 545 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 133 | 24% |
| Student > Master | 103 | 18% |
| Student > Bachelor | 74 | 13% |
| Researcher | 66 | 12% |
| Student > Doctoral Student | 42 | 7% |
| Other | 53 | 9% |
| Unknown | 90 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 146 | 26% |
| Agricultural and Biological Sciences | 142 | 25% |
| Medicine and Dentistry | 86 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 20 | 4% |
| Chemistry | 19 | 3% |
| Other | 46 | 8% |
| Unknown | 102 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2023.
All research outputs
#2,023,448
of 25,374,647 outputs
Outputs from Clinical and Translational Medicine
#80
of 1,060 outputs
Outputs of similar age
#19,195
of 292,501 outputs
Outputs of similar age from Clinical and Translational Medicine
#2
of 6 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,060 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.2. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 292,501 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.