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Beta cell function and ongoing autoimmunity in long-standing, childhood onset type 1 diabetes

Overview of attention for article published in Diabetologia, September 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

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21 tweeters

Citations

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13 Dimensions

Readers on

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25 Mendeley
Title
Beta cell function and ongoing autoimmunity in long-standing, childhood onset type 1 diabetes
Published in
Diabetologia, September 2016
DOI 10.1007/s00125-016-4087-0
Pubmed ID
Authors

Georgina M. Williams, Anna E. Long, Isabel V. Wilson, Rachel J. Aitken, Rebecca C. Wyatt, Timothy J. McDonald, F. Susan Wong, Andrew T. Hattersley, Alistair J. K. Williams, Polly J. Bingley, Kathleen M. Gillespie

Abstract

This study aimed to determine the frequency of residual beta cell function in individuals with long-standing type 1 diabetes who were recruited at diagnosis, and relate this to baseline and current islet autoantibody profile. Two hour post-meal urine C-peptide:creatinine ratio (UCPCR) and islet autoantibodies were measured in samples collected from 144 participants (median age at diagnosis: 11.7 years; 47% male), a median of 23 years (range 12-29 years) after diagnosis. UCPCR thresholds equivalent to mixed meal-stimulated serum C-peptide >0.001 nmol/l, ≥0.03 nmol/l and ≥0.2 nmol/l were used to define 'detectable', 'minimal' and 'residual/preserved') endogenous insulin secretion, respectively. Autoantibodies against GAD (GADA), islet antigen-2 (IA-2A), zinc transporter 8 (ZnT8A) and insulin (IAA) were measured by radioimmunoassay. Endogenous C-peptide secretion was detectable in 51 participants (35.4%), including residual secretion in seven individuals (4.9%) and minimal secretion in 14 individuals (9.7%). In the 132 samples collected more than 10 years after diagnosis, 86 participants (65.2%) had at least one islet autoantibody: 42 (31.8%) were positive for GADA, 69 (52.3%) for IA-2A and 14 of 104 tested were positive for ZnT8A (13.5%). The level of UCPCR was related to age at diagnosis (p = 0.002) and was independent of diabetes duration, and baseline or current islet autoantibody status. There is evidence of ongoing autoimmunity in the majority of individuals with longstanding diabetes. Endogenous insulin secretion continues for many years after diagnosis in individuals diagnosed with autoimmune-mediated type 1 diabetes above age 5. These findings suggest that some beta cells are protected from continued autoimmune attack in longstanding type 1 diabetes.

Twitter Demographics

The data shown below were collected from the profiles of 21 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 4%
Unknown 24 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 36%
Researcher 4 16%
Lecturer > Senior Lecturer 2 8%
Other 2 8%
Student > Doctoral Student 2 8%
Other 6 24%
Readers by discipline Count As %
Medicine and Dentistry 15 60%
Biochemistry, Genetics and Molecular Biology 4 16%
Unspecified 3 12%
Nursing and Health Professions 2 8%
Agricultural and Biological Sciences 1 4%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2016.
All research outputs
#1,051,534
of 12,290,236 outputs
Outputs from Diabetologia
#605
of 3,625 outputs
Outputs of similar age
#34,945
of 263,070 outputs
Outputs of similar age from Diabetologia
#20
of 83 outputs
Altmetric has tracked 12,290,236 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,625 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.1. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,070 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.