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Terpenoid bioactive compound from Streptomyces rochei (M32): taxonomy, fermentation and biological activities

Overview of attention for article published in World Journal of Microbiology & Biotechnology, August 2016
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  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

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2 tweeters

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8 Mendeley
Title
Terpenoid bioactive compound from Streptomyces rochei (M32): taxonomy, fermentation and biological activities
Published in
World Journal of Microbiology & Biotechnology, August 2016
DOI 10.1007/s11274-016-2121-5
Pubmed ID
Authors

Pazhanimurugan, Raasaiyah, Radhakrishnan, Manikkam, Shanmugasundaram, Thangavel, Gopikrishnan, Venugopal, Balagurunathan, Ramasamy

Abstract

The present study emphasized the production of biologically active terpenoid compound from Streptomyces rochei M32, which was isolated from Western Ghats ecosystem, South India. The presence of resistant genes like mecA, vanA of Staphylococcus aureus and bla SHV, bla TEM of Pseudomonas aeruginosa was confirmed by molecular studies. The isolated compound from Streptomyces rochei M32 inhibited wide range of standard and clinical drug resistant pathogens and enteric pathogens. The rice bran supplemented basal medium influenced the active compound production on 8th day of fermentation and yielded 1875 mg of crude extract from 10 g of rice bran substrate. Purification and characterization of crude ethyl acetate extract was achieved by preparative thin layer chromatography. The active fraction was identified as terpenoid class compound by chemical screening. Based on the results of spectral studies (NMR, LC-MS, FTIR, etc.), the active compound was tentatively identified as 1, 19-bis (3-hydroxyazetidin-1-yl) nonadeca-5, 14-diene-1, 8, 12, 19-tetraone with molecular weight 462.41 g/mol. Minimum inhibitory concentration value ranges between 7.6 and 31.2 µg/mL against test organisms was observed. The cytotoxicity results on cervical cancer (HeLa) cell line showed IC50 value of 2.034 µg/mL. The corresponding compound is not previously reported from any microbial resources.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 25%
Student > Ph. D. Student 2 25%
Professor 1 13%
Student > Bachelor 1 13%
Researcher 1 13%
Other 1 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 25%
Immunology and Microbiology 2 25%
Unspecified 1 13%
Agricultural and Biological Sciences 1 13%
Neuroscience 1 13%
Other 1 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 August 2016.
All research outputs
#4,168,294
of 8,286,032 outputs
Outputs from World Journal of Microbiology & Biotechnology
#175
of 571 outputs
Outputs of similar age
#128,215
of 252,710 outputs
Outputs of similar age from World Journal of Microbiology & Biotechnology
#8
of 24 outputs
Altmetric has tracked 8,286,032 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 571 research outputs from this source. They receive a mean Attention Score of 1.6. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,710 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.