| Title |
The interaction of Notch and Wnt signaling pathways in vertebrate regeneration
|
|---|---|
| Published in |
Cell Regeneration, April 2021
|
| DOI | 10.1186/s13619-020-00072-2 |
| Pubmed ID | |
| Authors |
Junying Gao, Lixia Fan, Long Zhao, Ying Su |
| Abstract |
Regeneration is an evolutionarily conserved process in animal kingdoms, however, the regenerative capacities differ from species and organ/tissues. Mammals possess very limited regenerative potential to replace damaged organs, whereas non-mammalian species usually have impressive abilities to regenerate organs. The regeneration process requires proper spatiotemporal regulation from key signaling pathways. The canonical Notch and Wnt signaling pathways, two fundamental signals guiding animal development, have been demonstrated to play significant roles in the regeneration of vertebrates. In recent years, increasing evidence has implicated the cross-talking between Notch and Wnt signals during organ regeneration. In this review, we summarize the roles of Notch signaling and Wnt signaling during several representative organ regenerative events, emphasizing the functions and molecular bases of their interplay in these processes, shedding light on utilizing these two signaling pathways to enhance regeneration in mammals and design legitimate therapeutic strategies. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 52 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 12% |
| Student > Master | 5 | 10% |
| Student > Doctoral Student | 3 | 6% |
| Student > Ph. D. Student | 2 | 4% |
| Other | 1 | 2% |
| Other | 6 | 12% |
| Unknown | 29 | 56% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 14 | 27% |
| Agricultural and Biological Sciences | 3 | 6% |
| Medicine and Dentistry | 2 | 4% |
| Neuroscience | 2 | 4% |
| Unspecified | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 29 | 56% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 June 2021.
All research outputs
#18,807,229
of 23,308,124 outputs
Outputs from Cell Regeneration
#116
of 159 outputs
Outputs of similar age
#321,597
of 431,714 outputs
Outputs of similar age from Cell Regeneration
#5
of 11 outputs
Altmetric has tracked 23,308,124 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 159 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 431,714 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.