Title |
Health-related quality of life after deep vein thrombosis
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Published in |
SpringerPlus, August 2016
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DOI | 10.1186/s40064-016-2949-z |
Pubmed ID | |
Authors |
Kristin Kornelia Utne, Mazdak Tavoly, Hilde Skuterud Wik, Lars Petter Jelsness-Jørgensen, René Holst, Per Morten Sandset, Waleed Ghanima |
Abstract |
Health-related quality of life (HRQoL) is known to be impaired in patients who develop post-thrombotic syndrome (PTS) following deep vein thrombosis (DVT). However, there is limited knowledge of the long-term HRQoL after DVT compared to controls without DVT. The objectives of this study were to evaluate long-term HRQoL following DVT and to compare that with age and sex matched control group and to population norms as well as to investigate possible predictors for reduced HRQoL. HRQoL was evaluated in 254 patients with confirmed DVT using the generic EQ-5D and the diseases specific VEINES-QOL/Sym questionnaire, whereas PTS was assessed by the Villalta scale. Patients were asked to give the EQ-5D questionnaire to two friends of same age- (±5 years) and sex (buddy controls). Patients scored significantly lower on all dimensions of EQ-5D compared to controls. EQ-5D index value was lower in patients compared with buddy controls; mean 0.79 (SD 0.17; IQR 0.72-1.00) versus 0.9 (SD 0.12; IQR 0.80-1.00), p < 0.001. EQ-5D index value was also significantly lower than age- and sex-adjusted population norms (p < 0.001). PTS and obesity (BMI >30/m(2)) were significantly associated with impaired HRQoL assessed by EQ-5D index value (odds ratio [OR] 11.0: 95 % confidence interval [CI] 4.6-29.7; and 2.3: 95 % CI 1.1-4.8, respectively) and VEINES-QOL (OR 28.2: 95 % CI 10.6-75.0; and OR 4.1: 95 % CI 1.7-9.7, respectively). Long-term HRQoL was significantly impaired in DVT patients compared with buddy controls and population norms. PTS and obesity were independently associated with impaired HRQoL. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 41 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 5 | 12% |
Researcher | 5 | 12% |
Student > Bachelor | 4 | 10% |
Student > Postgraduate | 4 | 10% |
Student > Ph. D. Student | 4 | 10% |
Other | 5 | 12% |
Unknown | 14 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 22% |
Nursing and Health Professions | 5 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Economics, Econometrics and Finance | 2 | 5% |
Other | 3 | 7% |
Unknown | 17 | 41% |