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PPAR agonists as effective adjuvants for COVID-19 vaccines, by modifying immunogenetics: a review of literature

Overview of attention for article published in Journal of Genetic Engineering and Biotechnology, May 2021
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#20 of 243)
  • Good Attention Score compared to outputs of the same age (71st percentile)

Mentioned by

twitter
7 tweeters

Citations

dimensions_citation
6 Dimensions

Readers on

mendeley
48 Mendeley
Title
PPAR agonists as effective adjuvants for COVID-19 vaccines, by modifying immunogenetics: a review of literature
Published in
Journal of Genetic Engineering and Biotechnology, May 2021
DOI 10.1186/s43141-021-00179-2
Pubmed ID
Authors

Antoine Fakhry AbdelMassih, Rahma Menshawey, Jumana H. Ismail, Reem J. Husseiny, Yousef M. Husseiny, Shenoda Yacoub, Aya Kamel, Rafeef Hozaien, Elaria Yacoub, Esraa Menshawey, Abanoub Abdelmalek, Ahmed Abouelazaem, Ahmed Elhatw, Ahmed Aboelmaaty, Alaaelrahman Shahib, Amany Mansour, Aya Kamal, Basant Mohamed, Bemen Atif, Beshoy Ghabreal, Catherine Abdelmalak, David Ibrahim, Ebtesam Elsaify, Farah Magdy, Farid G. Hanna, Hadeer Hafez, Hafsa Dahir, Kerlos Merhom, Maram Ahmed, Mariam Bishara, Mina Tawfik, Mina Youssef, Mohamed El Sharnouby, Mourad Hamouda, Musheera Ammar, Nada Ali, Nada Daniel, Nadine El-Husseiny, Noha Abdelraouf, Nuran K. Abdelhameed, Radwa Ahmed, Radwa Othman, Rahma Mohamadein, Rana Allam, Rana Elgendy, Rana Shebl, Saged Elsherbiney, Sarah Fouad, Sara Emel, Sara Owais, Sarah Hetta, Samah El-Saman, Shaimaa Abdelalim, Sherin Galal, Yara Asar, Yara Osman, Yasmeen Khalaf, Youstina Aziz, Yousra Khafagy, Nervana Gamal, Biagio Castaldi

Abstract

Several coronavirus vaccine have been fast-tracked to halt the pandemic, the usage of immune adjuvants that can boost immunological memory has come up to the surface. This is particularly of importance in view of the rates of failure of seroconversion and re-infection after COVID-19 infection, which could make the vaccine role and response debatable. Peroxisome proliferator-activated receptors (PPARs) have an established immune-modulatory role, but their effects as adjuvants to vaccination have not been explored to date. It is increasingly recognized that PPAR agonists can upregulate the levels of anti-apoptotic factors such as MCL-1. Such effect can improve the results of vaccination by enhancing the longevity of long-lived plasma cells (LLPCs). The interaction between PPAR agonists and the immune system does not halt here, as T cell memory is also stimulated through enhanced T regulatory cells, antagonizing PD-L1 and switching the metabolism of T cells to fatty acid oxidation, which has a remarkable effect on the persistence of T memory cells. What is even of a more significant value is the effect of PPAR gamma on ensuring a profound secretion of antibodies upon re-exposure to the offending antigen through upregulating lipoxin B4, therefore potentially assisting the vaccine response and deterring re-infection. In view of the above, we suggest the use of PPAR as adjuvants to vaccines in general especially the emerging COVID-19 vaccine due to their role in enhancing immunologic memory through DNA-dependent mechanisms.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 48 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 19%
Student > Master 5 10%
Researcher 3 6%
Librarian 3 6%
Other 3 6%
Other 7 15%
Unknown 18 38%
Readers by discipline Count As %
Medicine and Dentistry 12 25%
Biochemistry, Genetics and Molecular Biology 6 13%
Nursing and Health Professions 4 8%
Unspecified 1 2%
Arts and Humanities 1 2%
Other 5 10%
Unknown 19 40%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2022.
All research outputs
#5,374,858
of 22,526,255 outputs
Outputs from Journal of Genetic Engineering and Biotechnology
#20
of 243 outputs
Outputs of similar age
#100,037
of 352,398 outputs
Outputs of similar age from Journal of Genetic Engineering and Biotechnology
#1
of 1 outputs
Altmetric has tracked 22,526,255 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 243 research outputs from this source. They receive a mean Attention Score of 3.2. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,398 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them